SARMS Reviewed and Explained

What are SARMS?

SARMS DEFINED:

The word SARM stands for “Selective Androgen Receptor Modulator,” and just like the other selective receptor modulators, SARMS can either block, or stimulate, the same nuclear hormone receptors under different conditions. Consequently, if it can block or stimulate a receptor in a tissue selective manner, it may be able to mimic the beneficial effects in one tissue. And, at the same time, minimize the unwanted effects of the synthetic steroidal hormones in other tissues. Since SARMS are a class of androgens (a specific class of hormones that serve as ligands), they can bind to cellular androgen receptors. As a result, the androgen receptors will trigger a complex signal transduction pathway that will lead to a greater expression of specific genes.

what is sarmsSARMS VS. Anabolic Steroids

sarms-relative-to-dht-response-on-muscle-tissues-and-bones

In fact, anabolic androgenic steroids (AAS) and prohormones also bind to the androgen receptors, resulting in muscle growth. However, SARMS possess full anabolic activity in muscle and bone. Yet they have a minimal effect on the prostate as opposed to AAS, which can be very harmful to this gland. As an additional advantage, SARMS are orally available and require no injections. In spite of being oral compounds, SARMS are not methylated, so they are not liver toxic.

Due to the fact that SARMS are very specific to the androgen receptors, they can be extremely useful for safe muscle building. All in all, SARMS have an abundance of qualities. They are highly beneficial to bones, muscle tissues, and sexual function without the conversion of androgens into estrogens seen with steroids or prohormones.

Hence, SARMS offer the benefits of anabolic steroids, but they do not cause the side effects commonly associated with AAS. This quality makes them extremely desirable and intriguing to any class of users.

History of SARM

The development of steroidal SARMs started in the 1940’s with modifications made to the testosterone molecule. Since then, pharmaceutical companies have been testing SARMs for a variety of health benefits, which range from anti-obesity and bone health promotion, to fighting different diseases and counteracting muscle wasting.

Where do SARMS come from and why were they developed?

Steroids are generally prescribed by medical practitioners for two common reasons. The first, to treat muscle wasting diseases which usually take place with such conditions as cancer and osteoporosis. The other scenario takes place when steroids are prescribed for Hormonal or Testosterone Replacement Therapy (TRT). However, the main problem with steroids is that they often cause many unwanted effects. And they have pharmokinetic properties that are not desirable.

Testosterone SARM
Desirable effects Builds muscle
Promotes bone
Enhances libido
Undesirable effects Stimulation of prostate cancer
Virilization
Acne
Administration Oral dosing

Meanwhile, SARMS’ ability to stimulate a receptor in a tissue selective manner allows them to mimic the beneficial effects of androgen activation in muscles. At the same time the side effects of natural steroidal hormones can be minimized. In simple terms, SARMS are able to selectively induce muscle growth, avoiding the unwanted side effects.

Types of SARMs

There are 3 classes of SARMs in existence today:

  •  Ones in clinical testing, such as Ostarine, BMS, and LGD-4033
  • Several that are pre-clinical, such as AC, JNJ, LGD-2226/3303, and S-40503/23
  • Other SARMs, which are no longer developed, such as Andarine. Furthermore, GW-501516 is no longer being developed either. Technically speaking, it is not a SARM – it is a PPAR (peroxisome proliferator-activated receptors). However, it is a very popular drug to stack along with SARMs as part of double or triple stacks.

ostabolic-mk2866How many SARMS are there?

SARMS are constantly being studied and developed. What’s more, there are many compounds associated with SARMS, but by definition they are not actual SARMS. For instance, some of the mainstream compounds wrongly associated with SARMS are Cardarine (GW-501516) and Nutrobal (MK-677). The more mainstream SARMS that most know of are Ostarine – also known as Ostabolic – (MK-2866), Andarine (S4), Anabolicum (LGD-4033), Stenabolic (SR9009) and Testolone (RAD-140).

For more information on MK 2866, click here.

anabolicum-lgd-4033Why are SARMS beneficial?

As mentioned above, SARMS have steroid like results without the many unwanted side effects that AAS can cause. Here are the side effects of Anabolic Steroids (none of which are present with SARMS use).

  • Potential stimulation of prostate cancer
  • Male pattern baldness
  • Acne
  • Body hair growth
  • Gynecomastia (male breast development)
  • High blood pressure
  • Liver toxicity
  • Cholesterol imbalance
  • Left Ventricular Hypertrophy (Heart growth)
  • Suppression of the natural testosterone production
  • Water retention
  • Bloating

For more information on LGD-4033, click here.

Thus, SARMS are a much safer option to steroids because the selective stimulation of the androgen receptors only in bone and muscle tissue will prevent many, if not all, of the side effects listed above. Besides, they also have the advantages of oral dosing, which testosterone and some steroids do not have.

Who Can Use SARMs?

SARMs’ benefits could be extremely convenient to someone who is out of shape and/or overweight, and wants to use performance enhancing drugs (PED). If these individuals were to jump on steroids, they would experience major organ strain, estrogen related side effects (gynecomastia and high blood pressure for instance), and other major health problems that accompany AAS use. For them, it would be advantageous to use SARMs instead, as they are much safer and do not have those types of side effects.

Furthermore, SARMs could be very useful for someone who has taken a long time off from the gym, or who is totally new to androgens, since they are a good starting point in comparison to taking the plunge with extremely powerful and potentially risky anabolic steroids.

Interestingly, the experienced lifters can use certain SARMs during post cycle therapy and bridging, which is not possible with anabolic steroids due to their suppressive nature. As a matter of fact, SARMs can also help heal injuries, while anabolic steroids can make injuries worse. Actually, an example of injuries getting worse with AAS use would be joint issues that occur when cycling winstrol, masteron, or other dry compounds. However, certain SARMs will strengthen your joints and bones.

Finally, most SARMs have the advantage of not converting to estrogen, not being liver toxic, and not being screened for during some fitness related competitions.

andarine-s4

For more information on S-4, click here.

cardarine-gw501516How SARMS apply to bodybuilders

SARMS can be used by bodybuilders, gym users, fitness enthusiasts, or athletes either in conjunction with, or as a replacement for, traditional anabolic steroids for the following purposes:

  • Lean muscle growth
  • Prevention of muscle loss during cutting/weight loss
  • Injury rehabilitation
  • PCT use after AAS cycles

For more information on GW-501516, click here.

Benefits of SARMS:

  • Oral route of administration (no injections needed)
  • Similar effects to testosterone (libido, strength gains, fat loss, muscle growth, etc.)
  • No conversion to DHT (dihydrotestosterone – no problems with body hair growth, and hair loss on the head)
  • No conversion to estrogen
  • No liver toxicity that is usually seen with methylated compounds, such as prohormones and oral steroids
  • No inhibition of your HPTA to the large extent of steroids (minimal reduction in LH or FSH)
  • Legal to buy and use for research
  • Undetectable (certain SARMS)

Utilizing SARMS

bridge-stack

There are several possible ways to implement SARMS in you cycle, as they have a place and benefit in any situation. For example, SARMS became popular as a “bridge” in-between anabolic steroid cycles. Using them in this manner allows the user to have a much easier time keeping and/or adding to gains made on previous cycles. This can be done without having to worry about the side effects and drastic suppression one would experience with AAS use.

For more info on SARMS Bridge Stack, click here.

sarms-pct-stacksMoreover, some SARMS have shown to be extremely effective in post cycle therapy (PCT) protocols, rendering a user with an enhanced recovery process. Finally, SARMS have shown to not only compliment other anabolic compounds, but serve as an “enhancement for the enhancers.” In simple terms, they optimize the effects of anabolic steroids.

For more information on SARMS PCT stack, click here.

SARMS Cycles

SARMS can be cycled for any type of goal – cutting, recomposition or bulking. Over the years, SARMS have proven to be extremely versatile and have the capability to achieve any type of goal.

Nutrobal-mk677Generally, these compounds have an area where they truly shine, but when ran in a stack, the synergy between them allows maximum results. For instance, Testolone (RAD-140) and Anabolicum (LGD-4033) are best used in a bulking type of cycle, while Ostabolic (MK-2866) is best suited for a recomposition. On the other hand, for a cutting cycle one should opt for Andarine (S4) along with Cardarine (GW-501516) and Stenabolic (SR9009). At the same time, Nutrobal (MK677) will fit in any cycle, as it has the ability to cut fat and add great size at the same time. Hence, if chosen properly, SARMS can help you achieve any goal you desire.

For more information on MK-677, click here.

Usually, SARMS cycles tend to range from 12 to 16 weeks, depending upon the choice of the chemical. After the cycle completion, a mini post cycle therapy (mini pct) is all that is needed, as recovery from SARMS is much easier than with anabolic steroids. A small protocol of clomid and Cardarine during 4 weeks is more than enough. Then, a small rest period of 2-3 weeks is necessary before beginning again. In fact, Cardarine (GW) and Stenabolic (SR) require no PCT at all if ran alone. This is another characteristic that makes SARMS an optimal choice over AAS and PH use.

Phases of SARMs use

Sarms can be utilized in four different ways.

1. Recomp

This is probably the most popular way to use SARMs. Anabolic steroids do not burn fat, and we know this as a fact. However, SARMs do burn fat, so if you are looking to recomp and want to avoid shutting yourself down, SARMs can be utilized perfectly in this situation, especially combined with proper diet and cardio. Moreover, they have a great ability to add lean muscle mass while you burn fat, which makes them great for recomp.

2. Strength

SARMs can increase strength extremely rapidly because they bind to your androgen receptors so fast. The beauty part of this is that, unlike anabolic steroids, they can help heal joints, allowing you to go heavier without fearing injuries. This is very beneficial for those who always complain about nagging joint issues.

3. Cutting

The secret to SARM’s fat burning properties is their ability to decrease lipoprotein lapase enzyme, which will prevent fat from being added. Combine the PPAR GW to your SARMs stack, along with diet and cardio, and you can shred up very fast on a SARMs stack.

4. Bulking

Unfortunately, it is not the best way to utilize SARMs, but if you do not want to deal with HPTA (hypothalamic pituitary testicular axis) suppression, then you can most certainly bulk on them combined with weight training and increased calorie intake.

Side Effects of SARMS

How to use

SARMs come in liquid form, and it is not recommended to mix SARMs in a cup and then drink or to hold under the tongue. The proper way to ingest is simply squirt into the mouth your desired dosage and swallow it, then chase down with some water or juice. Dosages are dependent on the specific SARMs you are using, hence, please read future articles for individual information.

Where to buy

Unlike ordinary anabolic steroids, SARMs can be purchased legally in the US and other countries for research purposes in liquid form to be ingested. Obviously, it is illegal to use them for non-research purposes and they have been banned from all major sports, including the Olympic Games.

Therefore, finding a legitimate source is extremely important, as there are many fake and underdosed products being sold. The only place I would trust is SarmsX.com because they have the best products on the market.

sarms-benefits

Summary

Although SARMS are considered to be in an earlier phase of development, the potential for these compounds is very high, which is made evident by the number of pharmaceutical firms currently developing different SARM products.

As a summary, we can say that SARMS offer the following benefits:

  • Even though a slight HPTA suppression may be present at higher doses that are run for longer time periods, a stringent PCT is not necessary.
  • High oral bio-availabilty without any damage to your liver; compared to the nasty toxic effects of steroids and prohormones on the liver.
  • Anabolic even at low doses
  • Great for strength
  • Great for lean mass gains
  • Great for body recomposition
  • Great for endurance (aerobic or anaerobic)
  • Joint healing properties
View Article Source
SOURCES:

Evolutionary.org: “Selective Androgen Receptor Modulators (SARMS)”

NCBI, Holland-Frei Cancer Medicine. 6th edition., Mark J. Ratain, MD and William K. Plunkett, Jr, PhD.: “Principles of Pharmacokinetics”.

© 2015 iSARMS.com, LLC. All rights reserved.

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