originalbingham said:
Question on this stuff. From my understanding it's pretty much ghrp in a bottle. So the oral is super convenient. My question tho is people say they run it for 3 months and have great results. To me this makes no sense. It's still just a hormone releaser. Everyone says you have to run peptides or gh for 6 months or longer to reap the benefits. Now I'm not trying to knock mk677 by any means but I'd like to see if someone can explain what makes this so much better.
Also, can it be ran indefinitely? With other sarms you're suppose to take a break to clear receptors. Is that the same with mk677?
hey bro... im not quite sure where your getting the 3 months thing from? have you read the article i linked that i wrote earlier in the thread?
Here are some excerpts... answers to your questions about length of time to run it as well as side effects that are minimal as well as comparing it to other peptides that are supposed to be similar in functionality and showing what 677 does better...
The most frequent side-effects that were shown through human studies were increases in appetite, which is to be expected with the mimicking of ghrelin being involved. This showed to subside after 1-2 months of use. Other small side-effects present in some were mild lower extremity edema and muscle pain. There is a worry of prolactin increase as this is a common side effect with secretagogues, however human studies did not show this occurrence and this increase was reported on very rare occurrences in other logs reviewed. This is a problem that is not wanted at the peak of GH release if physical transformation is the intended goal. According to research, MK-677 increases GH and IGF-1 without a subsequent increase in Prolactin or Cortisol. GRF and GHRP-2,-6, all increase Prolactin and Cortisol, to a pretty significant degree. Ipamorelin stands alone as the only GHRP that has almost no effect on these other two hormones. So the fact that MK-677 increases growth hormone without the negative release of Prolactin and Cortisol is incredibly promising. By not increasing prolactin, MK-677 is a game changer as this is a substantial worry for many users. The last side-effect seen was extremely rare but was that of water retention. This is highly questionable as the subject was using other anabolics and supplements at the reported occurrence so a direct correlation with MK-677 may or may not be present. As can be ascertained from the list above, the side-effects are minimal at best.
DOSING:
When reading through the studies conducted, dosing ranged from 5mg-25 mg per day. The half life of MK-677 is 24 hours and is best tolerated when taken in the morning on an empty stomach. It provides a large improvement in sleep benefit however it can interfere with sleep if taken too late at night as opposed to the morning, making morning dosing optimal. The high end dosing protocol for MK-677 is 50 mg per day but it has shown to consistently be the best tolerated and show the most positive effect at 25 mg per day. It is fine to ease into it and assess your body response. It has shown to be best utilized in the safest and most effective manner at 25 mg per day. This dosing has shown to be the sweet spot. Many studies have shown MK-677 to be used in one and two year intervals with no adverse reactions and no desensitizing issues. This makes it very desirable for use as well.
