Anadrol does not directly convert to estrogen in the body. Oxymetholone is a derivative of dihydrotestosterone, which gives it a structure that cannot be aromatized. As such, many have speculated as to what makes this hormone so troublesome in terms of estrogenic side effects. Some have suggested that it has progestational activity, similar to nandrolone, and is not actually estrogenic at all. Since the obvious side effects of both estrogens and progestins are very similar, this explanation might be a plausible one. However we do find medical studies looking at this possibility. One such tested the progestational activity of various steroids including nandrolone, norethandrolone, methandrostenolone, testosterone and oxymetholone 3. It reported no significant progestational effect inherent in oxymetholone or methandrostenolone, slight activity with testosterone and strong progestational effect inherent in nandrolone and norethandrolone. With such findings it starts to seem much more likely that oxymetholone can intrinsically activate the estrogen receptor itself, similar to but more profoundly than the estrogenic androgen methAndriol. In speaking with chemist Patrick Arnold about my thoughts on this, I was afforded very believable support for my suspected . Anadrol has an acidic hydrogen in the A-ring at a vicinity that is approximate to where the acidic phenolic hydrogen of estradiol is. I suspect it is a potent estrogen agonist.
Clearly if this is the case we can only combat the estrogenic side effects of oxymetholone with estrogen receptor antagonists such as Nolvadexor Clomid, and not with an aromatase inhibitor. The strong anti-aromatase compounds such as Aromasin and Arimidex would similarly prove to be totally useless with this steroid, as aromatase is uninvolved.
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