Yes, it landed me a trip to the doctor's office and that was on 150mg a day. I broke out in hives all over my body and got incredibly sick. My doctor said it was a "serious case" and I had to take prednisone. Will that happen with everyone? Maybe not but google "DNP hives" it's common. It's not something you want to fuck around with and all this pro DNP shit won't go over well with the moderators here so please don't promote it.