About PIP from Dr B


Active member
Good reading from pops! Enjoy!

About PIP-

I will try to cover this as much as possible without being overly scientific and boring. Since this topic comes up so often, and has for so long been a problem it is time to try to figure it out. PIP,or painfull injection is one of our enemies. Let's do the best we can to avoid it. Especially full blown infections.

1) Tissue Irritation

This is probably the most likely cause of post injection pain and the least serious. Tissue irritation is likely to start 12-24 hours after injection, pain can be mild to moderate depending on the level of tissue irritation and the volume injected. The injection site is likely to swell within the muscle, maybe red and likely to be warm and very firm to the touch. The pain and swelling will start to fade after 72 hours and can last over a week in the worst cases.

The most likely causes of tissue irritation are:

1)-The hormone crashes out of the solution as soon as it is injected and the depot is placed rapidly deep into the muscle. This causes crystallization of the hormone, this in turn places a lot of pressure on the nerve endings in the muscle belly causing knotting, swelling and pain - this is most common in long chain esters that are made way too strong.And way too strong means anything over 300mg/ml. The body is made of roughly 65% water...and this water is salt water.The human water salinity % is about 0.9% .When these high concentrations are made, the hormone is not happy and wants to crash out of the oil. We trick the hormone by using solvents. Now when we inject this unstable high concentration, solutuion it hits and mixes up with our salty water, and immediately wants to start settling out or crashing as we say. And if you inject a water base solution then the body knows how to deal with water very easily,because it is water too. So water bases pip for the same reason that high mg gear does.Simply put the depot is there too soon,and too much.

2) A reaction to the acid compounds within the ester. With the metabolic breakdown of the ester attached to the hormone free form acids are released which can cause the muscle tissue rapid irritation at the injection site – this is most common with propionic acid of the propionate ester. Poor quality raw materials also liberate more free form acids. These things we call esters are simply carboxcylic acids that are saturated at the hook up point. The hormones such as test are attached to carboxylic acids and if the reaction in the production is not 100% complete then there is residual acid left in the hormone powder. Once deep in the muscle it irritates the muscle tissue. So if we make a bond between propionic acid and testosterone then we have made test pro. The better the process is, the better the hormone powder. Get a tiny bit sloppy in the process of hormone powder production and you have free acids in your gear.

3)Excessive preservative. If too much Benzyl Alcohol is used to preserve and maintain sterility, the solution may cause inflammation and pain. Pharma grade usually contains 0.9% Benzyl alcohol where some UGL products contain on average 2%. Anything above 1.2% offers no added anti-microbial effects. Due to the water soluble nature of benzyl alcohol, tissue irritation of this nature has been known to “travel” as the excessive alcohol disperses via the blood stream. This is most common with injection into the quads (vastus lateralis).The pain travels down toward the knee. This may however be in part due to lymphatic drainage which we will look at next. A less painfull antibacterial instead of BA would be chlorbutanol at less than 1%

You may find that ice, massage, some prefer warmth, and anti inflammatories will bring relief. This means asprin,ibuprofen, naproxen...not tylenol.Tylenol is not an anti inflammatory.

4) Hitting the lymphatic system.

Hitting the lymphatic system is very rare. The lymphatic system is as vast as the circulatory system but the standard injection sights (Glute, ventro-glute, medial delts and vastus lateralis) are generally void of lymphatic nodes. If a lymph node is hit with an injection, pain is likely to be severe and edema vast. The swelling will come on very fast and be extensive. It is also likely to “travel” along the lymph system to the next lymph gland. This is most noticeable with a vastus lateralis shot where the swelling tracks down toward the back of the knee. Unlike the edema experienced with tissue irritation (within the muscle only) the edema with a lymphatic puncture will be both inter and intra-muscular with a moderate amount of swelling just underneath the skin giving it a softer puffy feel.

Ice and ibuprofen may help. The affected area must be rested and the patient can expect pain and swelling to start to disperse after 72 hours and last at least 10 days. The painful area must not be massaged.

5) Infection and abscess.

So now to the most serious reason for injection pain. An infection will start in the same manner as tissue irritation with local pain and swelling, with heat and redness around the muscle. The major difference is that after 72 hours tissue irritation should start to subside, if the area is indeed infected, this pain and swelling will get worse. The swelling will change in nature becoming more systematic and edema will start to form under the skin becoming softer and more spongy (as described with a lymphatic puncture).

There are many reasons why an infection can manifest, below are some of the most common examples.

Poor injection technique. Correct, and sterile injection technique is a must. You must make sure the injection site and rubber septum is clean and swabbed with an alcohol wipe. Especially vulnerable is a septum to a water base aas. There are numerous bacteria that can live in the wet residue that you leave behind.

Also the moisture from the isopropyl alcohol (IPA) swab must be allowed to dry before preparing to inject. It is extremely rare but if the alcohol is not allowed to dry the bacterium has not been allowed adequate time to be killed off. If this partly destroyed bacterium was then pushed into a muscle through an Inter-muscular injection the bacterium can “evolve” into a superbug. Also an area wet with ipa will burn when injected simply due to ipa.

You should always use a clean and new syringe barrel and pin and not allow the pin to touch anything before you inject. Avoid pinning through a hair follicle or hair and don’t be tempted to inject too quickly. Injecting too quickly can increase the risk of infection as this in turn increases injection trauma.

Not rotating injection sites. The risk of infection is massively increased if the same injection site is used over and over again without giving it time to recover. The more an injury (injection trauma) is irritated (re-injected) the more likely it is to become infected. Think back to being a child and picking that scab on your knee excessively and then being told “I told you so” when it becomes a yellow puss infected mess.

Contaminated Gear. IMO this is probably the least common cause of infection. Even our ugl labs pay close attention to sterility . This is a no brainer really. Use a reputable UGL or pharm grade.

What to do in the case of an infection.

So the pain and swelling has not subsided and the edema is pitting and moving outside the confides of the muscle fascia after 72 hours. With an infection the body is attempting to contain the bacterium and prevent it from reaching the circulatory system by forming a cyst. This is essential to prevent blood poisoning. Firstly you need anti-biotics to help the body combat the infection, so take them ASAP. The quicker you start treatment the better chance you have of preventing the cyst growing and leaving a nice big hole in the muscle. The problem here is that the bacterium and infection is contained within a cyst which makes it very difficult for the antibiotics to penetrate. Normally with these types of infections,you will have a bit of fever. Anywhere from 101.5 to 102.5. As for antibiotics just plain old amoxcillan is good. You will need 500mg four times per day.A total 2000mg/day is good.

IMO the single most important thing you can do to ensure a rapid recovery, prevent a crator from forming in the infected muscle and avoid a “cut and drain” is to self aspirate the cyst. After 4-5 days of pain and after starting the anti-biotics. Take a syringe barrel at least 1ml larger than the injected volume and a very large gauge pin (18 gauge is ideal). This may hurt a little but the after effects are well worth it. Directly over the injection site the abscess will be the most swollen part, maybe discolored and will be spongy to touch. I have done this and you need to have some ibuprofen and maybe some Jack Daniels in your system.

Swab the area very well and slowly penetrate the 18g pin directly into the abscess. Keep pushing the pin in and gently aspirating every few millimeters until you hit the cyst. Slowly aspirate the cyst. You should be able to draw out the initial volume injected and then some blood and puss. You can expect to drain out 3ml from a 2ml injection 4-5 days post injection. This will give your immune system and the anti-biotics the best chance of fighting the infection. Always complete the course of anti-biotics even if the symptoms and swelling subside. A good course would be 10 days for 2000mg Amox.

So, we can easily see that prevention is the single best thing you can do. This whole situation with pip verifies the say..."an ounce of prevention is worth a pound of cure"

Dr.B. Debakey
Excellent post bro, I'm always saving posts like this in my bookmarks, so I could put it as an example at any time, or remind my self some bits.
Tnx man!
Great info Jake. Thanks for sharing!!

(PM me for a price list for Biotech Labs and 10% discount)
My ol lady removes cysts for a living she loves coming home and talking about the cut and drain stuff haha I'm like sicko
Hopefully this will cover some of our frequently asked questions on pip. If only people would search the forum a bit before asking lol

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Hopefully this will cover some of our frequently asked questions on pip. If only people would search the forum a bit before asking lol

Sent from my iPhone using Tapatalk

Yeah..agree. I bookmark stuff. The funny thing is today someone will ask "what is pip", and then "I have been reading about it"
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