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We need to talk about peptides... I know

stretch512

Member
What are peptides?

Peptides are short chain amino acid monomers linked by a peptide bond. The body utilizes these short amino acids chains to secrete/pulse growth hormone (GH) that is already stored in your body. This is a very attractive option for those who are not able to utilize synthetic human growth hormone (HGH) naturally. In fact, this could even be a safer alternative for those seeking to use growth hormone for recovery, anti-aging and fat-loss. There are a multitude of peptides on the market and new ones being created almost monthly. Therefore, for the sake of an overview, let me just touch upon the ones that are most commonly used. To begin, let me start by first breaking down the two most important peptide groups for bodybuilding.

GHRH & GHRP

Adults do not stop producing growth hormone as they get older; in fact, it’s a myth that’s spread by the HRT/TRT industry. However, as you get older, it’s harder to activate the body’s release or pulse of growth hormone as frequently as you did when you were still growing; hence, the term “when I was younger…”. Who doesn’t remember how great they felt at 18, versus 38!

It is important to understand that for growth hormone producing peptides we have two separate categories. On the forums, they have been mistakenly lumped together due to a misunderstanding of the chemical structure. Let’s separate fact from myth.

GHRH (Growth Hormone Releasing Hormones) cause the body to secrete a small amount of growth hormone. Depending upon the peptide, there can be short to long secreting times. Also, be aware that with most peptides there is a saturation dose (normally around 100mcg at a time). This means that going beyond the saturation dose will not produce an increase in growth hormone release. Experienced peptide users have indicated that saturation doses may actually be higher than 100mcg. However, this seems to depend on the purity of the peptides, and perhaps even based on the individual person themselves. In general, due to the nature of peptides, a lot of information has become anecdotal in nature rather than scientific.

GHRP (Growth Hormone Releasing Peptides) help facilitate a larger pulse of secreted growth hormone and do so more effectively than GHRH. While GHRH will increase the amount of growth hormone your body secretes, GHRP actually targets the pituitary and forces the growth hormone pulse.

Without going into great detail, think of GHRP’s as targeting a pulse when you want it; meaning, once you take it, you get a burst of GH. On the other hand, with GHRH’s you really have to time when your body will have its own pulse to get the most out of administering them. In simple terms, if you use GHRH’s at the wrong time, the results are minimal.

Saturation doses should also be taken into consideration with GHRP or any peptide for that matter. Knowing the saturation dose is important so users do not waste a peptide by going far beyond saturation doses.

The Work around is GHRH + GHRP. If GHRH help stimulate growth hormone and GHRP can stimulate twice as much, once you combine the two you are going to increase the amount of growth hormone that can be secreted by 12 times. GHRH will increase the amount of growth hormone that is secreted at the natural times when your body is ready to release the GH. GHRP will selectively send a pulse forcing GH to be secreted. Taking the two together, the GHRP will force a pulse and the GHRH will increase the power of that pulse. Basically, the power of that pulse will be greater, and with more frequency, when using GHRP and GHRH together. This combination gives the option for users to mix and match; thereby, finding which peptides work best for them.

IGF-1 and MGF

IGF-1 (Insulin-like growth factor) and MGF (Mechano-growth factor) are the peptides that help with insulin-like growth of muscles. In the case of mechano growth factor, it helps stimulate the recovery of damaged muscle tissue and activate satellite cells to produce more muscle tissue. MGF should only be dosed post workout and even on recovery days to utilize the full muscle building effects.

IGF IGF-1 can be taken pre workout or post workout. Both IGF and MGF are great for selectively targeting muscle groups and helping with lagging body parts.

Interestingly, it should be noted that while some steroids do increase IGF-1 production, it is nowhere near the amount that can be selectively targeted when injecting muscle groups with IGF-1.

So… now we get down to the individual peptides themselves. I will not go into length with a profile for each one, but instead I will provide two charts that should help in understanding which peptides are GHRH’s and which ones are GHRP’s. Of course, IGF and MGF have their own respective spots but do not have the synergy when combined like GHRP and GHRH.

As an extra note, there are a few things that should be mentioned about increased prolactin and cortisol levels when using certain peptides. My experience is with even high and frequent doses cortisol was raised but nothing to be alarmed about. Also, some peptides are sensitive to foods interfering with the peptides ability to take effect. Therefore, a safe rule of thumb is to not eat 30 minutes before and after dosing to make sure that no foods are facilitating the breakdown of these peptide chains upon subcutaneous or intramuscular injection.

Injections

Administration of peptides is normally subcutaneous or intramuscular. Peptides come as a fine white and delicate powder that must be reconstituted with bacteriostatic water or medical grade saline. An insulin syringe should always be used to administer the dose. When targeting muscles, look for a place where the layer of skin and fat are lean. Mixing two peptides in the same syringe is totally fine but I personally would advise not drawing/mixing doses and storing pins for future use.

Storage

Peptides can be stored before reconstituting them in the refrigerator or in a safe place out of the light and at least at room temperature. Once the peptide has been reconstituted, the vial must be stored in the refrigerator and out of the way of exposed light. The peptides amino acid chains are short so they will break down if not handled or stored properly. Keep the vials cool, and when you are ready to use draw the GHRH and GHRP into the same pin and administer as needed.

Conclusion

The conclusion comes down to which peptides should you use. This is going to depend on personal use and experience. Whether you are into bodybuilding, gaining an edge in sports or just looking for health and wellness and anti aging properties, peptides offer a little something for everyone. There are many peptides that are not covered below, but as an introduction into the peptide world these are the most generic and widely used. As with any supplement or drug, please do your own research before diving into using peptides.


Please see the attached pics as I have created two tables to help you better understand the peptides functions and pairing.

Peptide by generic type.jpg

Peptide by function.jpg
 
Excellent source of information bro! This is perfect for those looking for good general knowledge on peptides and their functions
 
I will try to upload a better pic of the table later. I have had good results with peptides but again I have gotten bad peptides too that did little. Not all peptides are bunk so please don't believe people spouting off about how they all come from China and all are bunk. There are no absolutes - I used peptides with great success and will look to continue to use them in the future. I can say stacking them with AAS or with SARMS also are great combo's. I ran trt dose, GW, Ipamorelin and CJC1295 w/Dac and was very impressed with my progress, endurance and recovery.
 
very good info... stretch has always been my go to guy for peptides and i encourage anyone with questions to go to him... he has my A+ approval for sure
 
I will try to upload a better pic of the table later. I have had good results with peptides but again I have gotten bad peptides too that did little. Not all peptides are bunk so please don't believe people spouting off about how they all come from China and all are bunk. There are no absolutes - I used peptides with great success and will look to continue to use them in the future. I can say stacking them with AAS or with SARMS also are great combo's. I ran trt dose, GW, Ipamorelin and CJC1295 w/Dac and was very impressed with my progress, endurance and recovery.

Have you ever used TB500 ?

I read that this is a great healing peptide but some people talk about endurance and muscle strength too, what do you think ? It could bee a good addition to SR/GW stack
 
Very good information bro. Peptides are definitely a weak point of knowledge for me. Thank you for the post

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Yes GHRP2 next to Ipamorelin has the highest ceiling and gives one of the biggest GH pulses among the GHRP family. GHRP2 with CJC with or without DAC are a very successful stack.

@tyrand TB500 is one of the few peptides I have not tried. I have never really had nagging injuries and if I have rehabbed from an injury I usually run high dose peptides or just grab some GH for a short run. I have seen many logs on TB500 and some are successful and some are questionable but its hard to tell since everyone is different. Some people may be training wrong or over training with an injury but there is no doubt the data shows it helps with rehab. Many have said it has helped but I have never had to find out for myself really.
 
Have you ever used TB500 ?

I read that this is a great healing peptide but some people talk about endurance and muscle strength too, what do you think ? It could bee a good addition to SR/GW stack

i have used tb500 several times and i love it... the problem is finding the quality out there which is extremely hard to find... if you do happen to get lucky and get quality, it works so well... it really helped me tremendously and when i stacked it with mk2866 it was unreal... adding it to a healing stack is perfect and really brings a lot of healing to your entire body
 
i have used tb500 several times and i love it... the problem is finding the quality out there which is extremely hard to find... if you do happen to get lucky and get quality, it works so well... it really helped me tremendously and when i stacked it with mk2866 it was unreal... adding it to a healing stack is perfect and really brings a lot of healing to your entire body
Is there a sponsor here that has quality peptides? Stretch, you would likely be the one to know. Maybe Dylan?

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Yes GHRP2 next to Ipamorelin has the highest ceiling and gives one of the biggest GH pulses among the GHRP family. GHRP2 with CJC with or without DAC are a very successful stack.

@tyrand TB500 is one of the few peptides I have not tried. I have never really had nagging injuries and if I have rehabbed from an injury I usually run high dose peptides or just grab some GH for a short run. I have seen many logs on TB500 and some are successful and some are questionable but its hard to tell since everyone is different. Some people may be training wrong or over training with an injury but there is no doubt the data shows it helps with rehab. Many have said it has helped but I have never had to find out for myself really.

Thanks bro
 
@iwannagofaster - I will PM you later with my peptide sources.

@carlsjr - For CJC W/O Dac + Ipamorelin this is what my dosing schedule looks like: CJC-1295 W/O Dac 1-3 time per day 100mcg-200mcg per injection. Remeber dosing should be 30mins before and after food intake. Ipamorelin can be dosed as high as 500mcg once per day or you can split up doses. I generally go about 100mcg in the morning 100mcg-200mcg in the evening. Ipamorelin does not have a saturation dose per say so you could technically dose it very high. But I think 500mcg is a good cut off point - not quite sure how much more effective it is beyond that dose.

Now if I use CJC 1295 W/ DAC then I do my daily Ipamorelin injections but split my CJC w/dac into 2-3 weekly injections. I will do 100-200mcg twice weekly. Adding the DAC on to the end of the CJC-1295 chain allows the peptide to circulate the body for days instead of hours which just mean less pinning in the end.
 
I would not suggest RUI. If you are interested in peptides become a member at datbtrue and there is a store within the community that is very reliable. Outside of that I have had luck with one site mainly called USpeptides. Not USA peptides! These guys only sell peptides and most of the generic ones we all know. They don't even sell TB but what they do have is legit.
 
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