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Chicken Shakes
Member
Or maybe its both?? DHT can cause enlarged prostrat, thats why finasteride helps but I have been reading the forums for about 8 yrs now and I have seen it mentioned that enlarged prostate happens from AAS mainly testosterone because it is the unmanaged high E2 causing the growth. I also have read that its the DHT that enlarges the prostate but its the high E2 thats responsible for cancer.
Doing research on S4 leads me to this Wiki. So S4 has been used in clinical trails to block DHT and NOT break down muscle with out the horrible side effects of finasteride.
Is there any evidence at this ti,e that S4 reduces the chances of prostate cancer??
From Wikipedia, the free encyclopedia
Andarine
Andarine.svg
Systematic (IUPAC) name
(2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
Clinical data
Legal status
Investigational new drug
Identifiers
CAS Registry Number 401900-40-1
ATC code None
PubChem CID: 9824562
IUPHAR/BPS 7849
DrugBank DB07423 Yes
ChemSpider 8000309 Yes
ChEMBL CHEMBL125236 Yes
Chemical data
Formula C19H18F3N3O6
Molecular mass 441.357 g/mol
SMILES[show]
InChI[show]
(what is this?) (verify)
Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,[1] using the non-steroidal androgen antagonist bicalutamide as a lead compound.[2]
Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.[3] This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.[4]
References[edit]
Jump up ^
Doing research on S4 leads me to this Wiki. So S4 has been used in clinical trails to block DHT and NOT break down muscle with out the horrible side effects of finasteride.
Is there any evidence at this ti,e that S4 reduces the chances of prostate cancer??
From Wikipedia, the free encyclopedia
Andarine
Andarine.svg
Systematic (IUPAC) name
(2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
Clinical data
Legal status
Investigational new drug
Identifiers
CAS Registry Number 401900-40-1
ATC code None
PubChem CID: 9824562
IUPHAR/BPS 7849
DrugBank DB07423 Yes
ChemSpider 8000309 Yes
ChEMBL CHEMBL125236 Yes
Chemical data
Formula C19H18F3N3O6
Molecular mass 441.357 g/mol
SMILES[show]
InChI[show]
(what is this?) (verify)
Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,[1] using the non-steroidal androgen antagonist bicalutamide as a lead compound.[2]
Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.[3] This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.[4]
References[edit]
Jump up ^
