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Disclaimer: If one chooses to supplement with a given compound, ultimately, the responsibility is on him/her to make sure they are well informed. This author feels that there is no substitute to making decisions based on guidelines set by professionals with experience using RAD-140.
Dylan had mentioned the low volume of evidence available regarding RAD-140 when we first embarked on collecting study information. Upon further investigation it quickly became apparent that Radius Health pharmaceuticals that have been pioneering this SARM have been keeping it under the radar, since they likely hope to capitalize on it when labeling it as a novel treatment for breast cancer. Since this compound is still at a very early preclinical stage, more significant information will only become relevant as it progresses to clinical trials.
Obviously, RAD-140 has shown a remarkable potential to increase lean body mass, but I elected to elaborate on other potential effects that may be of significance to the enhanced athlete.
What? Yes... I know it sounds pretty crazy. Bear with me on this. In a study on animal models[SUB](2)[/SUB] researchers hypothesized that since RAD-140 doesn't stimulate the prostate even in very high concentrations[SUB](2)[/SUB], but does stimulate the Androgen receptor, it may be able to compete with testosterone in the receptors of the prostate and in a manner of speaking - offset its negative effects.
It turned out that when RAD-140 was coadministered with testosterone propionate in animal models, the effects on the seminal vesicles and prostate(*) were mitigated, and the effects on muscle tissue were amplified.
The research team in the animal model study[SUB](2)[/SUB] were able to measure no change in liver enzyme parameters even in a dose that is 10 times greater than the minimal effective dose, in which RAD-140 stimulated increase in lean body mass. In effect this study concluded that “the compound has completed preclinical toxicology” and was deemed safe to investigate even on sick human subjects.
“we investigate the SARM RAD140... for its ability to provide neuroprotection, an important neural action of endogenous androgens that is relevant to neural health and resilience to neurodegenerative diseases”Our brain is actually an overwhelmingly metabolically active organ (for some more than for others). Nerve cells, like any other cell, are exposed to oxidative stress and age related changes throughout their lifetime. Since nerves, much like muscle and cartilage do not actively multiply following development, what you have – you have to take care of.
RAD-140, via androgen receptor derived mechanisms, have been shown to mimic other androgenic compounds' ability to defend and essentially neutralize the cellular pathway that results in cell damage and death in neuron cells.
Neurons treated with RAD-140 were more viable in the face of toxins and acids that kill brain cells.
This has been established both by cellular and animal models[SUB](3)[/SUB].
Thank you for reading, please supplement responsively.
References
(2)Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140; Chris P. Miller, Maysoun Shomali, C. Richard Lyttle, Louis St. L. O’Dea, Hillary Herendeen, Kyla Gallacher, Dottie Paquin, Dennis R. Compton, Bishwabhusan Sahoo, Sean A. Kerrigan, Matthew S. Burge, Michael Nickels, Jennifer L. Green, John A. Katzenellenbogen, Alexei Tchesnokov, Gary Hattersley ; ACS Medicinal Chemistry Letters (2010)
(3)Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats; Anusha Jayaraman, Amy Christensen, V. Alexandra Moser, Rebekah S. Vest, Chris P. Miller, Gary Hattersley, Christian J. Pike Journal of Endocrinology (2014)
(*) Effect on prostate specifically is statistically debatable, more subjects are required
Dylan had mentioned the low volume of evidence available regarding RAD-140 when we first embarked on collecting study information. Upon further investigation it quickly became apparent that Radius Health pharmaceuticals that have been pioneering this SARM have been keeping it under the radar, since they likely hope to capitalize on it when labeling it as a novel treatment for breast cancer. Since this compound is still at a very early preclinical stage, more significant information will only become relevant as it progresses to clinical trials.
Obviously, RAD-140 has shown a remarkable potential to increase lean body mass, but I elected to elaborate on other potential effects that may be of significance to the enhanced athlete.
Addition of RAD-140 to a testosterone base on a cycle could help eliminate testosterone's negative effect on the prostate.
What? Yes... I know it sounds pretty crazy. Bear with me on this. In a study on animal models[SUB](2)[/SUB] researchers hypothesized that since RAD-140 doesn't stimulate the prostate even in very high concentrations[SUB](2)[/SUB], but does stimulate the Androgen receptor, it may be able to compete with testosterone in the receptors of the prostate and in a manner of speaking - offset its negative effects.
It turned out that when RAD-140 was coadministered with testosterone propionate in animal models, the effects on the seminal vesicles and prostate(*) were mitigated, and the effects on muscle tissue were amplified.
"RAD-140 induces androgenic responses in muscle and brain, but not in reproductive tissues"[SUB](3)[/SUB]
RAD-140 has been shown to be liver safe. VERY liver safe
RAD-140 has been shown to be liver safe. VERY liver safe
The research team in the animal model study[SUB](2)[/SUB] were able to measure no change in liver enzyme parameters even in a dose that is 10 times greater than the minimal effective dose, in which RAD-140 stimulated increase in lean body mass. In effect this study concluded that “the compound has completed preclinical toxicology” and was deemed safe to investigate even on sick human subjects.
RAD-140 has shown the ability to protect your brain cells from oxidative stress and age related degeneration
“we investigate the SARM RAD140... for its ability to provide neuroprotection, an important neural action of endogenous androgens that is relevant to neural health and resilience to neurodegenerative diseases”
RAD-140, via androgen receptor derived mechanisms, have been shown to mimic other androgenic compounds' ability to defend and essentially neutralize the cellular pathway that results in cell damage and death in neuron cells.
Neurons treated with RAD-140 were more viable in the face of toxins and acids that kill brain cells.
This has been established both by cellular and animal models[SUB](3)[/SUB].
Thank you for reading, please supplement responsively.
References
(2)Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140; Chris P. Miller, Maysoun Shomali, C. Richard Lyttle, Louis St. L. O’Dea, Hillary Herendeen, Kyla Gallacher, Dottie Paquin, Dennis R. Compton, Bishwabhusan Sahoo, Sean A. Kerrigan, Matthew S. Burge, Michael Nickels, Jennifer L. Green, John A. Katzenellenbogen, Alexei Tchesnokov, Gary Hattersley ; ACS Medicinal Chemistry Letters (2010)
(3)Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats; Anusha Jayaraman, Amy Christensen, V. Alexandra Moser, Rebekah S. Vest, Chris P. Miller, Gary Hattersley, Christian J. Pike Journal of Endocrinology (2014)
(*) Effect on prostate specifically is statistically debatable, more subjects are required
