You mean coffee as a chaser? If that's what you are asking then Idk if that would be good(try a juice) lol I know a lot of people here say "just chug it down like a man!" but I prefer measuring out my liquid compounds, then using the dropper to fill up a 00 gelatin capsule(cheap as dirt on amazon). Then it's just like taking a fish oil or something.... no mess, nothing left in your mouth, no bad taste, etc. And then you can take it with any liquid. That's just my method... Others prefer just downing it with grapefruit juice.