a little know how.. (genetically gifted men, like in BB, have naturally lower levels of the myostatin protein in there blood)
The word "myostatin" come from the Ancient Greek μῦς (myo=muscle) and στατός (statin), which stand for "substance limiting the [growth of] muscle". Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promising therapy for muscle wasting. Myostatin, also known as GDF8 (growth differentiation factor 8), belongs to the transforming growth factor-β superfamily of secreted growth and differentiation factors. In common with the TGF-β family, myostatin is synthesized as a precursor protein consisting of a signal sequence, an inactive/ inhibitory N-terminal propeptide region and an invariant Arg-X-X-Arg proteolytic cleavage site, followed by a C-terminal domain which dimerizes to form the active/mature molecule. After cleavage of the signal sequence and proteolytic processing, the mature C-terminal dimer remains associated with the propeptide via non-covalent forces creating a latent complex from which myostatin must be released to elicit its biological activity. This latent complex circulates in the blood and can be activated by acid treatment.
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