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What an ester is, and how it works

TIN MAN

Member
WHAT AN ESTER IS, AND HOW IT WORKS,,,,,Copy and paste


I'm sure that if you have taken an interest in anabolic steroids you have noticed the similarities on the labeling of many drugs. Let's look at testosterone for example. One can find compounds like testosterone cypionate, enanthate, propionate, heptylate; caproate, phenylpropionate, isocaproate, decanoate, acetate, the list goes on and on. In all such cases the parent hormone is testosterone, which had been modified by adding an ester (enanthate, propionate etc.) to its structure. The following question arises: What is the difference between the various esterified versions of testosterone in regards to their use in bodybuilding?

An ester is a chain composed primarily of carbon and hydrogen atoms. This chain is typically attached to the parent steroid hormone at the 17th carbon position (beta orientation), although some compounds do carry esters at position 3 (for the purposes of this article it is not crucial to understand the exact position of the ester). Esterification of an injectable anabolic/androgenic steroid basically accomplishes one thing, it slows the release of the parent steroid from the site of injection. This happens because the ester will notably lower the water solubility of the steroid, and increase its lipid (fat) solubility. This will cause the drug to form a deposit in the muscle tissue, from which it will slowly enter into circulation as it is picked up in small quantities by the blood. Generally, the longer the ester chain, the lower the water solubility of the compound, and the longer it will take to for the full dosage to reach general circulation.

Slowing the release of the parent steroid is a great benefit in steroid medicine, as free testosterone (or other steroid hormones) previously would remain active in the body for a very short period of time (typically hours). This would necessitate an unpleasant daily injection schedule if one wished to maintain a continuous elevation of testosterone. By adding an ester, injections can be as infrequent as once per week or longer, instead of having to constantly re-administer the drug to achieve the desried effect. Clearly without the use of an ester, maintaining constant blood levels with an injectable anabolic/androgen would be much more difficult.

Esterification temporarily deactivates the steroid molecule. With a chain blocking the 17th beta position, binding to the androgen receptor is not possible (it can exert no activity in the body). In order for the compound to become active the ester must therefore first be removed. This automatically occurs once the compound has filtered into blood circulation, where esterase enzymes quickly cleave off (hydrolyze) the ester chain. This will restore the necessary hydroxyl (OH) group at the 17th beta position, enabling the drug to attach to the appropriate receptor. Now and only now will the steroid be able to have an effect on skeletal muscle tissue.

You can start to see why considering testosterone cypionate much more potent than enanthate makes little sense, as your muscles are seeing only free testosterone no matter what ester was used to deploy it.

ACTIONS OF DIFFERENT ESTERS


There are many different esters that are used with anabolic/androgenic steroids, but again, they all do basically the same thing. Esters vary only in their ability to reduce a steroid's water solubility. An ester like propionate for example will slow the release of a steroid for a few days, while the duration will be up to 15 days+/- with a decanoate ester. Esters have no effect on the tendency for the parent steroid to convert to estrogen or DHT (dihydrotestosterone: a more potent metabolite) nor will it effect the overall muscle-building potency of the compound. Any differences in results and side effects that may be noted by bodybuilders who have used various esterified versions of the same base steroid are just issues of timing.

*Testosterone enanthate causes estrogen related problems more readily than Sustanon, simply because with enanthate testosterone levels will peak and trough much sooner. Likewise testosterone suspension is the worst in regards to gyno and water bloat because blood hormone levels peak so quickly with this drug (propionate included). Instead of waiting weeks for testosterone levels to rise to their highest point, here we are at most looking at a couple of days. Given an equal blood level of testosterone, there would be no difference in the rate of aromatization or DHT conversion between different esters. There is simply no mechanism for this to be possible.

There is however one way that we can say an ester does technically effect potency; it is calculated in the steroid weight. The heavier the ester chain, the greater is its percentage of the total weight. In the case of testosterone enanthate for example, 250mg of esterified steroid (testosterone enanthate) is equal to only 180mg of free testosterone. 70mgs out of each 250mg injection is the weight of the ester. If we wanted to be really picky, we could consider enanthate slightly MORE potent than cypionate (I know this goes against popular thinking) as its ester chain contains one less carbon atom (therefore taking up a slightly smaller percentage of total weight). Propionate would of course come out on top of the three, releasing a measurable (but not significant) amount more testosterone per injection than cypionate or enanthate.

IN CONCLUSION

While the advent of esters certainly constitutes an invaluable advance in the field of anabolic steroid medicine, clearly you can see that there is no magic involved here. Esters work in a well-understood and predictable manner, and do not alter the activity of the parent steroid in any way other than to delay its release. Although the lure surrounding various steroid products like testosterone cypionate, Sustanon, Omnadren etc. certainly makes for interesting conversation, realistically it just amounts to misinformation that the athlete would be better off ignoring. Testosterone is testosterone and anyone who is going to tell you one ester form of this (or any) hormone is much better than another one should do a little more research, and a lot less talking.
 

RickRock

Community Leader
VIP Moderator
Good post and good info bro!


(PM me for a price list for Biotech Labs and 10% discount)
 

44YOGearHead

Active member
Member
Outstanding post... I tell people all the time test is test is test all the time. However the esterafication (spelling?) and it's effect on hormone delivery potency was something that really needed to be explained for folks. And thank you for explaining that suspension is in fact something that could in fact work more against you than for you rebound-wise. Refreshing read.

Sent from my SAMSUNG-SM-N900A using Tapatalk
 

Blue_Shine

Member
Member
Sweet read, brother!!! Loving it! It's nice to see a good insight towards the metabolism of these compounds to class up the joint a bit more. I'm way into this.

Thanks!!!
 

TIN MAN

Member
Thank you Guys............. LOL test prop is outdated ,,,,,Like me,,,,,,I have some TNE 100mg/ml on the way from BGS to add to my outdated Test P , NPP, Mast P
 

44YOGearHead

Active member
Member
NPP is a beautiful compound bro's... Tren is great as well - you just gotta find that balance point. For myself 600mg wasn't enough, but 900mgs was Assholeville for me.
 

BigBusiness

Active member
I was thinking about adding some Tren A 50mg eod with that but I'm scared to even that low dose, that is why the TNE for pre work out
I love TNE PWO. I wouldn't even add the tren to the mix, sounds great right where it is brother

PHARMACOM Board Rep
Faster Bigger Stronger
http://pharmacomstore.org
Worldwide Pharmacom Labs Official Distributor since 2008
 

buen

Banned
Test Ace is my go to....I love test ace because I pin everyday...on cycle or on TRT
Daily test ace keeps me rock solid stable on TRT....
On cycle I still pin daily but occasionally switch to daily Test E just to keep the volume of oil lower
 

buen

Banned
The half life is a little longer than prop and the molecular wieght of the ester is lower so you get slightly more mg's per dose

PHARMACOM Board Rep
Faster Bigger Stronger
http://pharmacomstore.org
Worldwide Pharmacom Labs Official Distributor since 2008

How can that be....ace is a shorter (lighter) ester...how can it have a longer half life?
I know many BB articles state props half life as 2 days and ace's as 3 days ..
but you also find many articles stating (correctly I believe) prop's half life as 4.5 days
Maybe someone with more chemistry knowledge can help clear this up
I know from how test ace reacts in my body it metabolizes faster than test prop
 
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