Continued:
What is Andarine (S-4)?
Andarine (S-4) is categorized as a SARM as well as a research chemical. S-4 was designed to treat several severe medical conditions, such as, muscle wasting, osteoporosis and benign prostatic hyptertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.
S-4 is an orally partial agonist for androgen receptors. Carrying this quality allows S4 to maintain and add lean body mass. When being compared to testosterone and other forms of steroids, the advantages of SARMS like S4, is they do not have androgenic activity in non-skeletal muscles.
S4 is often thought of as the strongest SARM, in terms of the many capabilities it has. It is a lean body mass builder, as well as strength and vascularity enhancer.
How does it work?
SARMS themselves bind to the AR (androgen receptor) and demonstrate osteo (bone) and myo (muscular anabolic activity. When something binds and activates the AR, it alters the expression of genes and increases protein synthesis, which in turn builds muscle.
SARMS cause muscle growth in the same method as steroids, the difference being that SARMS do not enhance the growth of ones prostate and other sexual organs. SARMS do not cause the many problems that anabolics can cause. SARMS do not have toxicity, in some circumstances only cause minimal suppression, allowing for a rapid recovery, as opposed to steroids that can cause long term problems from the high rates of suppression and provide a sense of well being each day that many steroids cannot cause.
S4 binds to the AR in muscle and bone at a third of the affinity as testosterone.
Evidence of S-4 Abilities?
Several studies have been conducted on S4. Here are some of the results found:
S4 dosed at 3 mg/kg/day had the ability to restore strength and skeletal muscle in castrated rats which proves it's ability for the treatment of muscle wasting and male HRT.
In a 120 day study comparing S4 to DHT (dihydrostesterone) treatment in overiectomized rats, showed S4 had the ability to maintain bone strength and mass and that S4 exhibited a much higher efficacy rate than DHT as well.
As noted earlier, S4 showed the ability to improve skeletal muscle strength but also to increase lean body mass, reduce body fat and prevent bone loss.
Strength gains and Lean mass gains
Andarine (S-4) is well known for the increases in strength that it provides. S4 provides huge amounts of strength, stamina and aides in rapid recovery. There is no estrogen conversion, no water retention or bloat and no toxicity. S4 is anabolic in nature so strength gains are obtained rapidly and lean mass is the primary attainment from use.
S-4 has a very short half life, spanning 4-6 hours, thus requiring multiple dosing. It is optimal to take one dose in the morning and another 4-6 hours later. Due to the short half life, many have found it to be optimal to take one dose 30 minutes prior to a workout, resulting with increased performance in the gym.
S-4 side effects
Andarine (S-4) does not carry many side effects but there is often one well known side effect commonly associated with use. It sounds far more than it actually is so a deep understanding of it is required. Many researchers often report night vision problems when using S4. These are not permanent and only present with S4 use. In short, a metabolite of S4 binds to the receptor in the eye, causing a yellow tint to appear when switching from dark to lighted areas, especially prevalent in the evenings. It is impossible to gauge if/when/how it binds and how bad the effect can be. Some barely experience it at all while others can find it more difficult to manage.
Although these side effects are temporary, if they are still a concern, as suggested earlier, a 5 on 2 off protocol where S-4 is used for 5 days followed by a 2 day break (then this cycle is repeated) would be the suggested research dosing method.
S4 does not aromatize, nor do any other SARMS. S4 has never shown any sort of estrogen elevation. Since it has slight androgenic activity, it gives the opposite effect and actually reduces any bloating present. The hardening effects S4 provides only confirms this.
Some users have shown very slight suppression when using S4. A short, mini post cycle therapy regiment is required with use, but the recovery time is only 2-3 weeks after completion.
Advantages Of S4 when compared to Steroids/Prohormones
S4 is non toxic and has no negative effect on the liver, blood pressure or any other internal organs.
There is not a full post cycle therapy nor recovery period required (generally only 2-3 weeks)
Researchers will have a far greater sense of well being while on S4
There is not a significant requirement for time off in between cycles.
S4 provides steroid like results without the steroid like side effects
WHAT IS MK-677
Nutrobal (MK-677) is a chemical that has the characteristics of human growth hormone (HGH). It is an orally active growth hormone secretagogue. A secretagogue causes substances to be secreted. MK677 has the ability because of its ability to mimic the GH stimulating action a hormone called “ghrelin.” Ghrelin is categorized as a peptide, commonly referred to as “the hunger hormone,” which explains the drastic rise in appetite with 677 use. Ghrelin plays a large role in regulating the distribution as well as rate of energy use. It is imperative to understand all of these concepts to decipher the many capabilities that 677 has. mk677 can not only increase plasma levels of many types of hormones, but also provide sustainable increases. These are long term and not just “for the time being” types of increases. Studies show that Nutrobal can increase muscle mass and bone mineral density as well as altering the metabolism of body fat, possibly becoming a treatment for obesity.
BENEFITS OF MK-677:
Nutrobal (MK-677) studies have been conducted since the late 90's. There is a wide array of benefits that have been found with use. The main benefit that consistently shows in study is the increase in growth hormone and IGF-levels provided with use. These have shown to be significant increases in regards to both. Below is a list of other significant benefits found through studies and implementation on humans:
Increases in fat free mass
Enhanced sleep quality
A treatment for obesity and fat loss
Lowering of bad cholesterol (LDL)
Significant improvements in nitrogen balance
Reversal of diet-induced nitrogen wasting
Treatment of catabolic conditions
Increase in basil metabolic rate
Oral administration (no injections required)
Overall sense of well-being
It is evident by the list of benefits that MK677 is highly desirable. These benefits, in conjunction with the very small chance of side effects show MK677 to be a breakthrough.
SIDE-EFFECTS:
As stated above, MK677 carries little to no side effects however it is always important to understand the possibilities that could occur with use.
The main “side effect” associated with MK677 is the increase in appetite, which may be welcome by many research subjects. Studies show this to subside after 4-8 weeks, variant from person to person. The other side effects that showed, that were very infrequent and uncommon were mild lower extremity edema and muscle pain. Secretagogues generally carry the worry of prolactin increase, however studies with MK677 did not show any increase in prolactin levels. Cortisol levels were not increased in studies either. These traits make Nutrobal stand out amongst other chemicals that attempt to work in the same manner but carry these unwanted side effects.
DOSING:
Studies conducted had dosing between 5-25 mg per day, with 25 mg being the most common and effective dose. MK677 has a 24 hour half life and showed to be best tolerated when fed to rats each morning on an empty stomach. MK677 has extreme benefits in regards to helping with a deeper sleep however it can interfere with sleep patterns if taken too late at night or too close to bed time. MK677 can be used continuously for 1-2 years with no concern of desensitizing.
