Competing for the Androgen receptor binding

[Dommo]

What's up everybody? My name is Dominic and I am having a dilemma because I think I don't understand the chemistry specifically related to Androgen receptor binding.

So I have cachexia and I'm trying to not lose weight and I found that some things were hard for me to access cuz I was living in Costa Rica although I just moved back to the States. I have lost so much weight it made me go on a hunt for things that could help with muscle wasting and because I had to take a whole bunch of corticosteroids and mineral steroids for an improper Addison's disease diagnosis for over 4 months, I also lost I'm sure a ton of bone mineral density.

So I bought Anadrol because I thought I could put on weight easily with that. And my plan was to take a quarter of the 50 mg tablet everyday for maybe 4 weeks. I am on trt but a very low dose cuz I'm a hyper responder. I am 6 ft normally way 200 lb but the cachexia brought me down to 168. Obviously I'm not looking to damage my liver and I don't know how long a person could run 12.5 mg but I would be willing to cut it 6.25 mg which would be 1/8 of a pill and combine it with other things that could work synergistically.

And here comes the Dilemma the other things that I'm looking at and interested in have a high binding affinity for the AR receptor and obviously Anadrol does too so does that mean they would be competing for the receptor? Then would I not get the games that I'm desiring? I wanted to run some LGd4033 at a super low dose since I know that can also be liver toxic and skew your lipid panel just like Anadrol so in my mind I had this great idea of taking:
3 mg sublingual lgd 4033
6.25 mg anadrol
90 mg trt
10g creatine mh
3g Betaine anhydrous
5g glycerol 65%
1.5g Nitrosigine
8g citrulline malate+beet root
8mg sublingual mk677


Basically I'm trying to add together as many things as I can think of the draw weight into the muscle one way or another whether it be water glycogen or nitrogen.. I just can't keep losing weight. Cachexia is horrible, I eat like a maniac and I have all my macros and macros in check and I just keep losing weight. And I know mk677 can give a little intracellular weight as well so I was going to cycle that in two maybe five days on 2 days off to try to keep sensitivity up.

So in my fantastic idea according to me I have covered all my bases as far as taking low doses of a ton of different compounds that can help a person gain weight.

I have every ancillary that I could think of on hand like HCG, HMG, Clomid(sublingual and capsule forms), novadex, TUDCA, inj glutathione, telmisartan and risuvistatin and I was considering getting some Arimidex just in case.

But, and I apologize for the super long introduction, but I don't have a lot of understanding and knowledge regarding these things and I have tried to do my best to research but I feel like I need help with this question if Anadrol and lgd will be competing for the receptor and instead of being synergistic, it will be a waste of time because probably lgd binds with a higher Affinity since it is specifically designed for that and also known to be one of the stronger bindings sarms as far as what I've read.

But then it just came into my mind like whoa Tren by and strongly to the AR and yet people take that with and draw and they don't have any problems except the obvious side effect problems. But what I mean is those two both find strong to the AR and I think even the PR also, although I'm not sure how strong anadrol does but I know that tren does.


So maybe people take them together because the Anadrol wins for the AR and the Trenbolone wins for the pr receptor so you get synergistic effects? I don't know. can somebody please explain this to me so I don't mix ligandrol with Anadrol and waste my time ruining my liver for nothing?

 

[Dommo]

This is what I meant to say. The problem is I use voice typing a lot and it doesn't hear me very well so it doesn't Translate like I said it. But this is what it was supposed to say

* " then it just came into my mind like whoa Tren binds strongly to the AR and yet people take that with anadrol and tren together and they don't have any problems concerning being able to stack them... except the obvious side effect problems being two hepatoxic possibly one or both nephrattoxic lipids and blood pressure... But what I mean is those two both bind strong to the AR and I think even the PR also, although I'm not sure how strong anadrol does but I know that tren does.


So maybe people take them together because the Anadrol wins for the AR and the Trenbolone wins for the PR receptor so you get synergistic effects? I don't know. can somebody please explain this to me so I don't mix ligandrol with Anadrol and waste my time ruining my liver for nothing?" *

 

[Mobsterthemod]

There's a LOT of misconceptions about the whole competing for receptors. Worth a podcast discussion I think

You also mention being a hyper responder which kinda doesn't sound correct or else I suspect, even allowing for the syndrome, you'd be having better results.

Also, as we did did a show on it, don't rely too much on voice typing or AI. It needs proofing every time

 

[stevesmi]

anabolic steroids work by breaking down barriers to help produce and environment to better add strength and muscle. no reason to overcomplicate it beyond that

 

[CEO]

What's up everybody? My name is Dominic and I am having a dilemma because I think I don't understand the chemistry specifically related to Androgen receptor binding.

So I have cachexia and I'm trying to not lose weight and I found that some things were hard for me to access cuz I was living in Costa Rica although I just moved back to the States. I have lost so much weight it made me go on a hunt for things that could help with muscle wasting and because I had to take a whole bunch of corticosteroids and mineral steroids for an improper Addison's disease diagnosis for over 4 months, I also lost I'm sure a ton of bone mineral density.

So I bought Anadrol because I thought I could put on weight easily with that. And my plan was to take a quarter of the 50 mg tablet everyday for maybe 4 weeks. I am on trt but a very low dose cuz I'm a hyper responder. I am 6 ft normally way 200 lb but the cachexia brought me down to 168. Obviously I'm not looking to damage my liver and I don't know how long a person could run 12.5 mg but I would be willing to cut it 6.25 mg which would be 1/8 of a pill and combine it with other things that could work synergistically.

And here comes the Dilemma the other things that I'm looking at and interested in have a high binding affinity for the AR receptor and obviously Anadrol does too so does that mean they would be competing for the receptor? Then would I not get the games that I'm desiring? I wanted to run some LGd4033 at a super low dose since I know that can also be liver toxic and skew your lipid panel just like Anadrol so in my mind I had this great idea of taking:
3 mg sublingual lgd 4033
6.25 mg anadrol
90 mg trt
10g creatine mh
3g Betaine anhydrous
5g glycerol 65%
1.5g Nitrosigine
8g citrulline malate+beet root
8mg sublingual mk677


Basically I'm trying to add together as many things as I can think of the draw weight into the muscle one way or another whether it be water glycogen or nitrogen.. I just can't keep losing weight. Cachexia is horrible, I eat like a maniac and I have all my macros and macros in check and I just keep losing weight. And I know mk677 can give a little intracellular weight as well so I was going to cycle that in two maybe five days on 2 days off to try to keep sensitivity up.

So in my fantastic idea according to me I have covered all my bases as far as taking low doses of a ton of different compounds that can help a person gain weight.

I have every ancillary that I could think of on hand like HCG, HMG, Clomid(sublingual and capsule forms), novadex, TUDCA, inj glutathione, telmisartan and risuvistatin and I was considering getting some Arimidex just in case.

But, and I apologize for the super long introduction, but I don't have a lot of understanding and knowledge regarding these things and I have tried to do my best to research but I feel like I need help with this question if Anadrol and lgd will be competing for the receptor and instead of being synergistic, it will be a waste of time because probably lgd binds with a higher Affinity since it is specifically designed for that and also known to be one of the stronger bindings sarms as far as what I've read.

But then it just came into my mind like whoa Tren by and strongly to the AR and yet people take that with and draw and they don't have any problems except the obvious side effect problems. But what I mean is those two both find strong to the AR and I think even the PR also, although I'm not sure how strong anadrol does but I know that tren does.


So maybe people take them together because the Anadrol wins for the AR and the Trenbolone wins for the pr receptor so you get synergistic effects? I don't know. can somebody please explain this to me so I don't mix ligandrol with Anadrol and waste my time ruining my liver for nothing?

Bros. You overthinking things too much.
Steroids are not black and white
gonna be a lot of variations to what people get.

 

[ROIDDERS]

This is what I meant to say. The problem is I use voice typing a lot and it doesn't hear me very well so it doesn't Translate like I said it. But this is what it was supposed to say

* " then it just came into my mind like whoa Tren binds strongly to the AR and yet people take that with anadrol and tren together and they don't have any problems concerning being able to stack them... except the obvious side effect problems being two hepatoxic possibly one or both nephrattoxic lipids and blood pressure... But what I mean is those two both bind strong to the AR and I think even the PR also, although I'm not sure how strong anadrol does but I know that tren does.


So maybe people take them together because the Anadrol wins for the AR and the Trenbolone wins for the PR receptor so you get synergistic effects? I don't know. can somebody please explain this to me so I don't mix ligandrol with Anadrol and waste my time ruining my liver for nothing?" *

I would not overthink things. It's very important to make sure that you have your diet and your training on point if you want to get the most out of anabolic steroids.

 

[bodymonster34]

What's up everybody? My name is Dominic and I am having a dilemma because I think I don't understand the chemistry specifically related to Androgen receptor binding.

So I have cachexia and I'm trying to not lose weight and I found that some things were hard for me to access cuz I was living in Costa Rica although I just moved back to the States. I have lost so much weight it made me go on a hunt for things that could help with muscle wasting and because I had to take a whole bunch of corticosteroids and mineral steroids for an improper Addison's disease diagnosis for over 4 months, I also lost I'm sure a ton of bone mineral density.

So I bought Anadrol because I thought I could put on weight easily with that. And my plan was to take a quarter of the 50 mg tablet everyday for maybe 4 weeks. I am on trt but a very low dose cuz I'm a hyper responder. I am 6 ft normally way 200 lb but the cachexia brought me down to 168. Obviously I'm not looking to damage my liver and I don't know how long a person could run 12.5 mg but I would be willing to cut it 6.25 mg which would be 1/8 of a pill and combine it with other things that could work synergistically.

And here comes the Dilemma the other things that I'm looking at and interested in have a high binding affinity for the AR receptor and obviously Anadrol does too so does that mean they would be competing for the receptor? Then would I not get the games that I'm desiring? I wanted to run some LGd4033 at a super low dose since I know that can also be liver toxic and skew your lipid panel just like Anadrol so in my mind I had this great idea of taking:
3 mg sublingual lgd 4033
6.25 mg anadrol
90 mg trt
10g creatine mh
3g Betaine anhydrous
5g glycerol 65%
1.5g Nitrosigine
8g citrulline malate+beet root
8mg sublingual mk677


Basically I'm trying to add together as many things as I can think of the draw weight into the muscle one way or another whether it be water glycogen or nitrogen.. I just can't keep losing weight. Cachexia is horrible, I eat like a maniac and I have all my macros and macros in check and I just keep losing weight. And I know mk677 can give a little intracellular weight as well so I was going to cycle that in two maybe five days on 2 days off to try to keep sensitivity up.

So in my fantastic idea according to me I have covered all my bases as far as taking low doses of a ton of different compounds that can help a person gain weight.

I have every ancillary that I could think of on hand like HCG, HMG, Clomid(sublingual and capsule forms), novadex, TUDCA, inj glutathione, telmisartan and risuvistatin and I was considering getting some Arimidex just in case.

But, and I apologize for the super long introduction, but I don't have a lot of understanding and knowledge regarding these things and I have tried to do my best to research but I feel like I need help with this question if Anadrol and lgd will be competing for the receptor and instead of being synergistic, it will be a waste of time because probably lgd binds with a higher Affinity since it is specifically designed for that and also known to be one of the stronger bindings sarms as far as what I've read.

But then it just came into my mind like whoa Tren by and strongly to the AR and yet people take that with and draw and they don't have any problems except the obvious side effect problems. But what I mean is those two both find strong to the AR and I think even the PR also, although I'm not sure how strong anadrol does but I know that tren does.


So maybe people take them together because the Anadrol wins for the AR and the Trenbolone wins for the pr receptor so you get synergistic effects? I don't know. can somebody please explain this to me so I don't mix ligandrol with Anadrol and waste my time ruining my liver for nothing?

bro just get on tren and call it a day
tren make the man !

 

[Ulter]

What's up everybody? My name is Dominic and I am having a dilemma because I think I don't understand the chemistry specifically related to Androgen receptor binding.

So I have cachexia and I'm trying to not lose weight and I found that some things were hard for me to access cuz I was living in Costa Rica although I just moved back to the States. I have lost so much weight it made me go on a hunt for things that could help with muscle wasting and because I had to take a whole bunch of corticosteroids and mineral steroids for an improper Addison's disease diagnosis for over 4 months, I also lost I'm sure a ton of bone mineral density.

So I bought Anadrol because I thought I could put on weight easily with that. And my plan was to take a quarter of the 50 mg tablet everyday for maybe 4 weeks. I am on trt but a very low dose cuz I'm a hyper responder. I am 6 ft normally way 200 lb but the cachexia brought me down to 168. Obviously I'm not looking to damage my liver and I don't know how long a person could run 12.5 mg but I would be willing to cut it 6.25 mg which would be 1/8 of a pill and combine it with other things that could work synergistically.

And here comes the Dilemma the other things that I'm looking at and interested in have a high binding affinity for the AR receptor and obviously Anadrol does too so does that mean they would be competing for the receptor? Then would I not get the games that I'm desiring? I wanted to run some LGd4033 at a super low dose since I know that can also be liver toxic and skew your lipid panel just like Anadrol so in my mind I had this great idea of taking:
3 mg sublingual lgd 4033
6.25 mg anadrol
90 mg trt
10g creatine mh
3g Betaine anhydrous
5g glycerol 65%
1.5g Nitrosigine
8g citrulline malate+beet root
8mg sublingual mk677


Basically I'm trying to add together as many things as I can think of the draw weight into the muscle one way or another whether it be water glycogen or nitrogen.. I just can't keep losing weight. Cachexia is horrible, I eat like a maniac and I have all my macros and macros in check and I just keep losing weight. And I know mk677 can give a little intracellular weight as well so I was going to cycle that in two maybe five days on 2 days off to try to keep sensitivity up.

So in my fantastic idea according to me I have covered all my bases as far as taking low doses of a ton of different compounds that can help a person gain weight.

I have every ancillary that I could think of on hand like HCG, HMG, Clomid(sublingual and capsule forms), novadex, TUDCA, inj glutathione, telmisartan and risuvistatin and I was considering getting some Arimidex just in case.

But, and I apologize for the super long introduction, but I don't have a lot of understanding and knowledge regarding these things and I have tried to do my best to research but I feel like I need help with this question if Anadrol and lgd will be competing for the receptor and instead of being synergistic, it will be a waste of time because probably lgd binds with a higher Affinity since it is specifically designed for that and also known to be one of the stronger bindings sarms as far as what I've read.

But then it just came into my mind like whoa Tren by and strongly to the AR and yet people take that with and draw and they don't have any problems except the obvious side effect problems. But what I mean is those two both find strong to the AR and I think even the PR also, although I'm not sure how strong anadrol does but I know that tren does.


So maybe people take them together because the Anadrol wins for the AR and the Trenbolone wins for the pr receptor so you get synergistic effects? I don't know. can somebody please explain this to me so I don't mix ligandrol with Anadrol and waste my time ruining my liver for nothing?

i think you just have to start using them and learning how they work
you can study every book you want and listen to every video online
it won't help you as much as trying them out

 

[2Thick]

I don't believe in any of this receptor crap. If it was true, then there would be no point in professional bodybuilders, using like 15 different things at once.

 

[Dommo]

Im so grateful for everyones imput. Thank you... I never thought the combining would be an issue but I asked google AI and it gave me this explanation about LG winning for the spot on the Androgen receptor over Anadrol so I got worried and figured I'd ask a forum where there would be knowledgeable people. And just as you guys said , the top guys are combining so many compounds and it's not an issue . So I am going to take you guys advice and just test the waters and see what works and what doesn't work . One thing though, I eat Surplus and then some but it just doesn't seem to matter even with all the supplements and vitamins and getting enough protein and also I don't have an appetite so it's all forced and very difficult to do but I just can't keep losing weight so I know these compounds are going to help. Thank you guys for taking your time

 

[Dommo]

And regarding tren.. I totally would if I had access to it but I have no way of getting it. I just lucked out that where I lived you could just go to any pharmacy and get something on and that a friend of mine had some Anadrol. But the trest and lgd4033 and everything else was easy to buy online from these sarm and peptide companies.

 

[Dommo]

And regarding tren.. I totally would if I had access to it but I have no way of getting it. I just lucked out that where I lived you could just go to any pharmacy and get something on and that a friend of mine had some Anadrol. But the trest and lgd4033 and everything else was easy to buy online from these sarm and peptide companies.

Not "SOMETHING ON"... sustanon... Sorry... I was living in Costa Rica for 15 years and you could just get Sustanon from any place. I guess I didn't learn my lesson on The Voice typing. What an idiot

 

[RickRock]

You are overthinking the shit out of it. The androgen receptor competing thing is garbage. Just take what makes sense to you and eat for gains and let the cards fall in their place

 

[Noah Wixx]

There's a LOT of misconceptions about the whole competing for receptors. Worth a podcast discussion I think

You also mention being a hyper responder which kinda doesn't sound correct or else I suspect, even allowing for the syndrome, you'd be having better results.

Also, as we did did a show on it, don't rely too much on voice typing or AI. It needs proofing every time

Id enjoy a podcast on this topic