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What is MK-677?? IN DEPTH ARTICLE BY: Dylan Gemelli

DylanGemelli

Founding Member
Super Moderator
MK 677 – The Facts

By: Dylan Gemelli


Advances in every aspect of life are formulated and developed by the second. Individuals all over the world work by the second to find improvements, enhancements and better ways to go about anything and everything. We have all seen this in the bodybuilding community with the development of SARMS. The term SARMS stands for “Selective Androgen Receptor Modulators.” SARMS offer the benefits of anabolic androgenic steroids while offering a far lower occurrence of side effects. This characteristic has allowed SARMS to grow in popularity by the day and the rise in use is ever growing. There is a SARM that is often overlooked or not understood as the more mainstream or well-known SARMS. This particular SARM is called MK-677 (Ibutamoren). I am going to provide and in depth understanding of what it is, how it works and studies that have been conducted to back the information that is provided. MK-677 is proving to be a breakthrough and the information below will show why.

TABLE OF CONTENTS

1. Introduction
2. What is MK-677
3. Benefits of MK-677
4. Side-effects
5. Studies Conducted
6. Dosing
7. Conclusion

INTRODUCTION:

The world of SARMS is ever growing and new ideas on what to formulate next are constantly being worked on through creation and study. The benefits with SARMS are extremely high while keeping side effects to a minimum, if any at times. These are characteristics that qualify the term “breakthrough” when describing them. When new formulas are created to provide such drastic effects and results, it is a breakthrough because these types of concepts and characteristics are extremely rare.
As you continue to read, you will see and understand what exactly MK-677 is and why it is quickly becoming sought after by so many.

WHAT IS MK-677?

MK-677 is a SARM that acts as an extremely potent, orally active growth hormone secretagogue. A secretagogue is a substance that causes another substance to be secreted. MK 677 has this ability by mimicking the GH stimulating action of the hormone ghrelin. Ghrelin is a peptide that is referred to as “the hunger hormone”. It is produced by ghrelin cells in the GI tract which functions as a neuropeptide in the central nervous system. Ghrelin also plays a significant role in regulating the distribution and rate of energy use. It is important to understand these concepts to understand all the capabilities MK-677 possesses. MK-677 has shown to not only increase the release of but also produce sustained increases in plasma levels of many types of hormones. At the top of this list are growth hormone and IGF-1, all the while with no affect on cortisol levels. At this time, it is under development as a treatment for reduced levels of both hormones. Examples of this treatment would include growth hormone deficient individuals. Human studies have shown that MK-677 will increase both bone mineral density and muscle mass. MK-677 also alters metabolism of body fat and so may have application in the treatment of obesity.




Results: Daily administration of MK-677 significantly increased growth hormone and insulin-like growth factor I levels to those of healthy young adults without serious adverse effects.

BENEFITS OF MK-677:

Studies have been on going with MK-677 since the late 90's. The list of benefits that have been found through this studies is not only significant in amount but in category as well. MK-677 has several different benefits and has shown to be helpful in a variety of ways. The main benefit that continues to be consistent is the increase in growth hormone and IGF-1 levels. This has shown to be the main benefit that is seen with MK-677. These increases are not small increases. They have shown to consistently be significant increases in both levels respectively. These are benefits that are extremely desirable but the list does not stop there. This results is consistent throughout the many clinical trials thus far. Below is a list of other significant benefits found through studies and implementation on humans:

Increases in fat free mass
Enhanced sleep quality
A treatment for obesity and fat loss
Lowering of bad cholesterol (LDL)
Significant improvements in nitrogen balance
Reversal of diet-induced nitrogen wasting
Treatment of catabolic conditions
Increase in basil metabolic rate
Oral administration (no injections required)
Overall sense of well-being

These benefits have all been seen with consistency throughout clinical studies. Human logs seen on many bodybuilding forums throughout the internet have also confirmed these benefits as been true and accurate. MK-677 has shown to increase muscle mass and bone density, while also decreasing fat mass. While many know that GH itself is very useful for fat loss, it has always fallen short in studies researching Growth Hormone’s effect on muscle protein synthesis. As can be seen by the extensive list, there is a significant size of benefits offered with implementation of MK-677. There is a sizable amount of intrigue and interest after seeing several results and studies that are consistent in showing the strong capabilities of MK-677. These factors, coupled with the little to no possible side-effects make MK-677 as very desirable addition into supplemental regiments for many individuals.


SIDE-EFFECTS:

Any time you are putting a substance into your body, it is is vital to know and understand the possible side-effects that could be endured. Whether these are probable or unlikely to occur, it is important to be fully educated on all possibilities and know how to treat them or control them if there is an occurrence. As stated above, one of the highly desirable attributes of use with MK-677 is the lack of side-effects present. Through intense research with human studies and personal logs, findings of side-effects are rare but there are small instances that need to be brought to attention.

The most frequent side-effects that were shown through human studies were increases in appetite, which is to be expected with the mimicking of ghrelin being involved. This showed to subside after 1-2 months of use. Other small side-effects present in some were mild lower extremity edema and muscle pain. There is a worry of prolactin increase as this is a common side effect with secretagogues, however human studies did not show this occurrence and this increase was reported on very rare occurrences in other logs reviewed. This is a problem that is not wanted at the peak of GH release if physical transformation is the intended goal. According to research, MK-677 increases GH and IGF-1 without a subsequent increase in Prolactin or Cortisol. GRF and GHRP-2,-6, all increase Prolactin and Cortisol, to a pretty significant degree. Ipamorelin stands alone as the only GHRP that has almost no effect on these other two hormones. So the fact that MK-677 increases growth hormone without the negative release of Prolactin and Cortisol is incredibly promising. By not increasing prolactin, MK-677 is a game changer as this is a substantial worry for many users. The last side-effect seen was extremely rare but was that of water retention. This is highly questionable as the subject was using other anabolics and supplements at the reported occurrence so a direct correlation with MK-677 may or may not be present. As can be ascertained from the list above, the side-effects are minimal at best.

STUDIES CONDUCTED:

There are studies dating back as far as 1997 with MK-677. Below, you will find a list of links with several studies conducted and a small description on what was being studied with MK-677 use. These are all human studies and provide substantial insight.


1997: Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults

http://press.endocrine.org/doi/full/10. ... 82.10.4297


1997: MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism

http://press.endocrine.org/doi/abs/10.1 ... lCode=jcem

1998: Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.

http://www.ncbi.nlm.nih.gov/pubmed/9661080

1997: Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.

www.ncbi.nlm.nih.gov/pubmed/9349662

1999: Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group.
http://www.ncbi.nlm.nih.gov/pubmed/10404019
2001: Effects of oral administration of ibutamoren mesylate, a non peptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children.

http://www.ncbi.nlm.nih.gov/pubmed/11452249

1997: Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure

http://press.endocrine.org/doi/full/10. ... .83.2.4539

This is a small sample of several studies conducted over time in regard to MK-677 use and the benefits its provides. The results have remained consistent, showing substantial benefits in each study.

DOSING:

When reading through the studies conducted, dosing ranged from 5mg-25 mg per day. The half life of MK-677 is 24 hours and is best tolerated when taken in the morning on an empty stomach. It provides a large improvement in sleep benefit however it can interfere with sleep if taken too late at night as opposed to the morning, making morning dosing optimal. The high end dosing protocol for MK-677 is 50 mg per day but it has shown to consistently be the best tolerated and show the most positive effect at 25 mg per day. It is fine to ease into it and assess your body response. It has shown to be best utilized in the safest and most effective manner at 25 mg per day. This dosing has shown to be the sweet spot. Many studies have shown MK-677 to be used in one and two year intervals with no adverse reactions and no desensitizing issues. This makes it very desirable for use as well.


CONCLUSION:

MK-677 is showing it's effectiveness regularly when implemented into supplementation. There are consistent findings and studies to back up all claims. There are major benefits show with use, especially in regard to consistent and large increases in IGF and GH levels. The large amount of benefits coupled with the miniscule amounts of side-effects make MK-677 extremely desirable. Research and study continues but through more than a decade of study, the results show MK-677 to be highly effective and beneficial in several aspects.
 

RickRock

Community Leader
VIP Moderator
DylanGemelli said:
MK 677 – The Facts

By: Dylan Gemelli


Advances in every aspect of life are formulated and developed by the second. Individuals all over the world work by the second to find improvements, enhancements and better ways to go about anything and everything. We have all seen this in the bodybuilding community with the development of SARMS. The term SARMS stands for “Selective Androgen Receptor Modulators.” SARMS offer the benefits of anabolic androgenic steroids while offering a far lower occurrence of side effects. This characteristic has allowed SARMS to grow in popularity by the day and the rise in use is ever growing. There is a SARM that is often overlooked or not understood as the more mainstream or well-known SARMS. This particular SARM is called MK-677 (Ibutamoren). I am going to provide and in depth understanding of what it is, how it works and studies that have been conducted to back the information that is provided. MK-677 is proving to be a breakthrough and the information below will show why.

TABLE OF CONTENTS

1. Introduction
2. What is MK-677
3. Benefits of MK-677
4. Side-effects
5. Studies Conducted
6. Dosing
7. Conclusion

INTRODUCTION:

The world of SARMS is ever growing and new ideas on what to formulate next are constantly being worked on through creation and study. The benefits with SARMS are extremely high while keeping side effects to a minimum, if any at times. These are characteristics that qualify the term “breakthrough” when describing them. When new formulas are created to provide such drastic effects and results, it is a breakthrough because these types of concepts and characteristics are extremely rare.
As you continue to read, you will see and understand what exactly MK-677 is and why it is quickly becoming sought after by so many.

WHAT IS MK-677?

MK-677 is a SARM that acts as an extremely potent, orally active growth hormone secretagogue. A secretagogue is a substance that causes another substance to be secreted. MK 677 has this ability by mimicking the GH stimulating action of the hormone ghrelin. Ghrelin is a peptide that is referred to as “the hunger hormone”. It is produced by ghrelin cells in the GI tract which functions as a neuropeptide in the central nervous system. Ghrelin also plays a significant role in regulating the distribution and rate of energy use. It is important to understand these concepts to understand all the capabilities MK-677 possesses. MK-677 has shown to not only increase the release of but also produce sustained increases in plasma levels of many types of hormones. At the top of this list are growth hormone and IGF-1, all the while with no affect on cortisol levels. At this time, it is under development as a treatment for reduced levels of both hormones. Examples of this treatment would include growth hormone deficient individuals. Human studies have shown that MK-677 will increase both bone mineral density and muscle mass. MK-677 also alters metabolism of body fat and so may have application in the treatment of obesity.




Results: Daily administration of MK-677 significantly increased growth hormone and insulin-like growth factor I levels to those of healthy young adults without serious adverse effects.

BENEFITS OF MK-677:

Studies have been on going with MK-677 since the late 90's. The list of benefits that have been found through this studies is not only significant in amount but in category as well. MK-677 has several different benefits and has shown to be helpful in a variety of ways. The main benefit that continues to be consistent is the increase in growth hormone and IGF-1 levels. This has shown to be the main benefit that is seen with MK-677. These increases are not small increases. They have shown to consistently be significant increases in both levels respectively. These are benefits that are extremely desirable but the list does not stop there. This results is consistent throughout the many clinical trials thus far. Below is a list of other significant benefits found through studies and implementation on humans:

Increases in fat free mass
Enhanced sleep quality
A treatment for obesity and fat loss
Lowering of bad cholesterol (LDL)
Significant improvements in nitrogen balance
Reversal of diet-induced nitrogen wasting
Treatment of catabolic conditions
Increase in basil metabolic rate
Oral administration (no injections required)
Overall sense of well-being

These benefits have all been seen with consistency throughout clinical studies. Human logs seen on many bodybuilding forums throughout the internet have also confirmed these benefits as been true and accurate. MK-677 has shown to increase muscle mass and bone density, while also decreasing fat mass. While many know that GH itself is very useful for fat loss, it has always fallen short in studies researching Growth Hormone’s effect on muscle protein synthesis. As can be seen by the extensive list, there is a significant size of benefits offered with implementation of MK-677. There is a sizable amount of intrigue and interest after seeing several results and studies that are consistent in showing the strong capabilities of MK-677. These factors, coupled with the little to no possible side-effects make MK-677 as very desirable addition into supplemental regiments for many individuals.


SIDE-EFFECTS:

Any time you are putting a substance into your body, it is is vital to know and understand the possible side-effects that could be endured. Whether these are probable or unlikely to occur, it is important to be fully educated on all possibilities and know how to treat them or control them if there is an occurrence. As stated above, one of the highly desirable attributes of use with MK-677 is the lack of side-effects present. Through intense research with human studies and personal logs, findings of side-effects are rare but there are small instances that need to be brought to attention.

The most frequent side-effects that were shown through human studies were increases in appetite, which is to be expected with the mimicking of ghrelin being involved. This showed to subside after 1-2 months of use. Other small side-effects present in some were mild lower extremity edema and muscle pain. There is a worry of prolactin increase as this is a common side effect with secretagogues, however human studies did not show this occurrence and this increase was reported on very rare occurrences in other logs reviewed. This is a problem that is not wanted at the peak of GH release if physical transformation is the intended goal. According to research, MK-677 increases GH and IGF-1 without a subsequent increase in Prolactin or Cortisol. GRF and GHRP-2,-6, all increase Prolactin and Cortisol, to a pretty significant degree. Ipamorelin stands alone as the only GHRP that has almost no effect on these other two hormones. So the fact that MK-677 increases growth hormone without the negative release of Prolactin and Cortisol is incredibly promising. By not increasing prolactin, MK-677 is a game changer as this is a substantial worry for many users. The last side-effect seen was extremely rare but was that of water retention. This is highly questionable as the subject was using other anabolics and supplements at the reported occurrence so a direct correlation with MK-677 may or may not be present. As can be ascertained from the list above, the side-effects are minimal at best.

STUDIES CONDUCTED:

There are studies dating back as far as 1997 with MK-677. Below, you will find a list of links with several studies conducted and a small description on what was being studied with MK-677 use. These are all human studies and provide substantial insight.


1997: Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults

http://press.endocrine.org/doi/full/10. ... 82.10.4297


1997: MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism

http://press.endocrine.org/doi/abs/10.1 ... lCode=jcem

1998: Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.

http://www.ncbi.nlm.nih.gov/pubmed/9661080

1997: Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.

http://www.ncbi.nlm.nih.gov/pubmed/9349662

1999: Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group.
http://www.ncbi.nlm.nih.gov/pubmed/10404019
2001: Effects of oral administration of ibutamoren mesylate, a non peptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children.

http://www.ncbi.nlm.nih.gov/pubmed/11452249

1997: Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure

http://press.endocrine.org/doi/full/10. ... .83.2.4539

This is a small sample of several studies conducted over time in regard to MK-677 use and the benefits its provides. The results have remained consistent, showing substantial benefits in each study.

DOSING:

When reading through the studies conducted, dosing ranged from 5mg-25 mg per day. The half life of MK-677 is 24 hours and is best tolerated when taken in the morning on an empty stomach. It provides a large improvement in sleep benefit however it can interfere with sleep if taken too late at night as opposed to the morning, making morning dosing optimal. The high end dosing protocol for MK-677 is 50 mg per day but it has shown to consistently be the best tolerated and show the most positive effect at 25 mg per day. It is fine to ease into it and assess your body response. It has shown to be best utilized in the safest and most effective manner at 25 mg per day. This dosing has shown to be the sweet spot. Many studies have shown MK-677 to be used in one and two year intervals with no adverse reactions and no desensitizing issues. This makes it very desirable for use as well.


CONCLUSION:

MK-677 is showing it's effectiveness regularly when implemented into supplementation. There are consistent findings and studies to back up all claims. There are major benefits show with use, especially in regard to consistent and large increases in IGF and GH levels. The large amount of benefits coupled with the miniscule amounts of side-effects make MK-677 extremely desirable. Research and study continues but through more than a decade of study, the results show MK-677 to be highly effective and beneficial in several aspects.


Awesome information Dylan! MK-677 looks even better than I anticipated. I'm very interested in the positive effects of it, and trying it out before going with GH which is obviously considerably more expensive. It appears that MK-677 can be ran and should be ran for a considerable amount of time (like GH) for best results. This is something I can't wait to try out for myself to see what it can do for me :D
 

DylanGemelli

Founding Member
Super Moderator
RickRock said:
DylanGemelli said:
MK 677 – The Facts

By: Dylan Gemelli


Advances in every aspect of life are formulated and developed by the second. Individuals all over the world work by the second to find improvements, enhancements and better ways to go about anything and everything. We have all seen this in the bodybuilding community with the development of SARMS. The term SARMS stands for “Selective Androgen Receptor Modulators.” SARMS offer the benefits of anabolic androgenic steroids while offering a far lower occurrence of side effects. This characteristic has allowed SARMS to grow in popularity by the day and the rise in use is ever growing. There is a SARM that is often overlooked or not understood as the more mainstream or well-known SARMS. This particular SARM is called MK-677 (Ibutamoren). I am going to provide and in depth understanding of what it is, how it works and studies that have been conducted to back the information that is provided. MK-677 is proving to be a breakthrough and the information below will show why.

TABLE OF CONTENTS

1. Introduction
2. What is MK-677
3. Benefits of MK-677
4. Side-effects
5. Studies Conducted
6. Dosing
7. Conclusion

INTRODUCTION:

The world of SARMS is ever growing and new ideas on what to formulate next are constantly being worked on through creation and study. The benefits with SARMS are extremely high while keeping side effects to a minimum, if any at times. These are characteristics that qualify the term “breakthrough” when describing them. When new formulas are created to provide such drastic effects and results, it is a breakthrough because these types of concepts and characteristics are extremely rare.
As you continue to read, you will see and understand what exactly MK-677 is and why it is quickly becoming sought after by so many.

WHAT IS MK-677?

MK-677 is a SARM that acts as an extremely potent, orally active growth hormone secretagogue. A secretagogue is a substance that causes another substance to be secreted. MK 677 has this ability by mimicking the GH stimulating action of the hormone ghrelin. Ghrelin is a peptide that is referred to as “the hunger hormone”. It is produced by ghrelin cells in the GI tract which functions as a neuropeptide in the central nervous system. Ghrelin also plays a significant role in regulating the distribution and rate of energy use. It is important to understand these concepts to understand all the capabilities MK-677 possesses. MK-677 has shown to not only increase the release of but also produce sustained increases in plasma levels of many types of hormones. At the top of this list are growth hormone and IGF-1, all the while with no affect on cortisol levels. At this time, it is under development as a treatment for reduced levels of both hormones. Examples of this treatment would include growth hormone deficient individuals. Human studies have shown that MK-677 will increase both bone mineral density and muscle mass. MK-677 also alters metabolism of body fat and so may have application in the treatment of obesity.




Results: Daily administration of MK-677 significantly increased growth hormone and insulin-like growth factor I levels to those of healthy young adults without serious adverse effects.

BENEFITS OF MK-677:

Studies have been on going with MK-677 since the late 90's. The list of benefits that have been found through this studies is not only significant in amount but in category as well. MK-677 has several different benefits and has shown to be helpful in a variety of ways. The main benefit that continues to be consistent is the increase in growth hormone and IGF-1 levels. This has shown to be the main benefit that is seen with MK-677. These increases are not small increases. They have shown to consistently be significant increases in both levels respectively. These are benefits that are extremely desirable but the list does not stop there. This results is consistent throughout the many clinical trials thus far. Below is a list of other significant benefits found through studies and implementation on humans:

Increases in fat free mass
Enhanced sleep quality
A treatment for obesity and fat loss
Lowering of bad cholesterol (LDL)
Significant improvements in nitrogen balance
Reversal of diet-induced nitrogen wasting
Treatment of catabolic conditions
Increase in basil metabolic rate
Oral administration (no injections required)
Overall sense of well-being

These benefits have all been seen with consistency throughout clinical studies. Human logs seen on many bodybuilding forums throughout the internet have also confirmed these benefits as been true and accurate. MK-677 has shown to increase muscle mass and bone density, while also decreasing fat mass. While many know that GH itself is very useful for fat loss, it has always fallen short in studies researching Growth Hormone’s effect on muscle protein synthesis. As can be seen by the extensive list, there is a significant size of benefits offered with implementation of MK-677. There is a sizable amount of intrigue and interest after seeing several results and studies that are consistent in showing the strong capabilities of MK-677. These factors, coupled with the little to no possible side-effects make MK-677 as very desirable addition into supplemental regiments for many individuals.


SIDE-EFFECTS:

Any time you are putting a substance into your body, it is is vital to know and understand the possible side-effects that could be endured. Whether these are probable or unlikely to occur, it is important to be fully educated on all possibilities and know how to treat them or control them if there is an occurrence. As stated above, one of the highly desirable attributes of use with MK-677 is the lack of side-effects present. Through intense research with human studies and personal logs, findings of side-effects are rare but there are small instances that need to be brought to attention.

The most frequent side-effects that were shown through human studies were increases in appetite, which is to be expected with the mimicking of ghrelin being involved. This showed to subside after 1-2 months of use. Other small side-effects present in some were mild lower extremity edema and muscle pain. There is a worry of prolactin increase as this is a common side effect with secretagogues, however human studies did not show this occurrence and this increase was reported on very rare occurrences in other logs reviewed. This is a problem that is not wanted at the peak of GH release if physical transformation is the intended goal. According to research, MK-677 increases GH and IGF-1 without a subsequent increase in Prolactin or Cortisol. GRF and GHRP-2,-6, all increase Prolactin and Cortisol, to a pretty significant degree. Ipamorelin stands alone as the only GHRP that has almost no effect on these other two hormones. So the fact that MK-677 increases growth hormone without the negative release of Prolactin and Cortisol is incredibly promising. By not increasing prolactin, MK-677 is a game changer as this is a substantial worry for many users. The last side-effect seen was extremely rare but was that of water retention. This is highly questionable as the subject was using other anabolics and supplements at the reported occurrence so a direct correlation with MK-677 may or may not be present. As can be ascertained from the list above, the side-effects are minimal at best.

STUDIES CONDUCTED:

There are studies dating back as far as 1997 with MK-677. Below, you will find a list of links with several studies conducted and a small description on what was being studied with MK-677 use. These are all human studies and provide substantial insight.


1997: Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults

http://press.endocrine.org/doi/full/10. ... 82.10.4297


1997: MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism

http://press.endocrine.org/doi/abs/10.1 ... lCode=jcem

1998: Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.

http://www.ncbi.nlm.nih.gov/pubmed/9661080

1997: Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.

http://www.ncbi.nlm.nih.gov/pubmed/9349662

1999: Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group.
http://www.ncbi.nlm.nih.gov/pubmed/10404019
2001: Effects of oral administration of ibutamoren mesylate, a non peptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children.

http://www.ncbi.nlm.nih.gov/pubmed/11452249

1997: Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure

http://press.endocrine.org/doi/full/10. ... .83.2.4539

This is a small sample of several studies conducted over time in regard to MK-677 use and the benefits its provides. The results have remained consistent, showing substantial benefits in each study.

DOSING:

When reading through the studies conducted, dosing ranged from 5mg-25 mg per day. The half life of MK-677 is 24 hours and is best tolerated when taken in the morning on an empty stomach. It provides a large improvement in sleep benefit however it can interfere with sleep if taken too late at night as opposed to the morning, making morning dosing optimal. The high end dosing protocol for MK-677 is 50 mg per day but it has shown to consistently be the best tolerated and show the most positive effect at 25 mg per day. It is fine to ease into it and assess your body response. It has shown to be best utilized in the safest and most effective manner at 25 mg per day. This dosing has shown to be the sweet spot. Many studies have shown MK-677 to be used in one and two year intervals with no adverse reactions and no desensitizing issues. This makes it very desirable for use as well.


CONCLUSION:

MK-677 is showing it's effectiveness regularly when implemented into supplementation. There are consistent findings and studies to back up all claims. There are major benefits show with use, especially in regard to consistent and large increases in IGF and GH levels. The large amount of benefits coupled with the miniscule amounts of side-effects make MK-677 extremely desirable. Research and study continues but through more than a decade of study, the results show MK-677 to be highly effective and beneficial in several aspects.


Awesome information Dylan! MK-677 looks even better than I anticipated. I'm very interested in the positive effects of it, and trying it out before going with GH which is obviously considerably more expensive. It appears that MK-677 can be ran and should be ran for a considerable amount of time (like GH) for best results. This is something I can't wait to try out for myself to see what it can do for me :D


Lets put it this way brother... 1. It should not be confused with GH as being as strong nor as effective HOWEVER, it has "GH Like properties and abilities which has earned it the synonym of "GH in a bottle." Just to be abundantly clear... I AM NOT SAYING NOR ADVOCATING IT to be the same or as strong etc. HOWEVER, it has MAJOR capabilities and for someone that is uncomfortable with GH use, THIS is the safer and best alternative to get LIKE results... 2. There's a reason you did not see as much on this as WE SHOULD HAVE because it would have directly taken out of the pockets of sarms1 ownership. They refused to ever add it to the lineup, despite SEVERAL months of my urging and YOU KNOW WHY, because of 2 reasons... The first being they simply did not offer it in the store and that would have sent customers elsewhere ultimately resulting in a loss of business as other companies were tried and see to be far better and two, the raws for 677 are 3-4 times more expensive and you cannot underdose this and get away with it all so they have no way to scam on it... The margins were not there enough, even though they would still be good but greed took away from something this amazing because it really is amazing if you have the quality... I am sure noone is surprised by the facts given about it though...
 

ibleedoranbla

Active member
I'm using mk677 from another supplier right now. I can't wait to get my hands on some pure essence mk677. SIGN ME UP haha
 

JackSteel

Banned
Nice write up dude. I wonder how this stands up to peptides. Would be a good thing to experiment with.


Sent from my iPhone using Tapatalk
 

RickRock

Community Leader
VIP Moderator
DylanGemelli said:
RickRock said:
DylanGemelli said:
MK 677 – The Facts

By: Dylan Gemelli


Advances in every aspect of life are formulated and developed by the second. Individuals all over the world work by the second to find improvements, enhancements and better ways to go about anything and everything. We have all seen this in the bodybuilding community with the development of SARMS. The term SARMS stands for “Selective Androgen Receptor Modulators.” SARMS offer the benefits of anabolic androgenic steroids while offering a far lower occurrence of side effects. This characteristic has allowed SARMS to grow in popularity by the day and the rise in use is ever growing. There is a SARM that is often overlooked or not understood as the more mainstream or well-known SARMS. This particular SARM is called MK-677 (Ibutamoren). I am going to provide and in depth understanding of what it is, how it works and studies that have been conducted to back the information that is provided. MK-677 is proving to be a breakthrough and the information below will show why.

TABLE OF CONTENTS

1. Introduction
2. What is MK-677
3. Benefits of MK-677
4. Side-effects
5. Studies Conducted
6. Dosing
7. Conclusion

INTRODUCTION:

The world of SARMS is ever growing and new ideas on what to formulate next are constantly being worked on through creation and study. The benefits with SARMS are extremely high while keeping side effects to a minimum, if any at times. These are characteristics that qualify the term “breakthrough” when describing them. When new formulas are created to provide such drastic effects and results, it is a breakthrough because these types of concepts and characteristics are extremely rare.
As you continue to read, you will see and understand what exactly MK-677 is and why it is quickly becoming sought after by so many.

WHAT IS MK-677?

MK-677 is a SARM that acts as an extremely potent, orally active growth hormone secretagogue. A secretagogue is a substance that causes another substance to be secreted. MK 677 has this ability by mimicking the GH stimulating action of the hormone ghrelin. Ghrelin is a peptide that is referred to as “the hunger hormone”. It is produced by ghrelin cells in the GI tract which functions as a neuropeptide in the central nervous system. Ghrelin also plays a significant role in regulating the distribution and rate of energy use. It is important to understand these concepts to understand all the capabilities MK-677 possesses. MK-677 has shown to not only increase the release of but also produce sustained increases in plasma levels of many types of hormones. At the top of this list are growth hormone and IGF-1, all the while with no affect on cortisol levels. At this time, it is under development as a treatment for reduced levels of both hormones. Examples of this treatment would include growth hormone deficient individuals. Human studies have shown that MK-677 will increase both bone mineral density and muscle mass. MK-677 also alters metabolism of body fat and so may have application in the treatment of obesity.




Results: Daily administration of MK-677 significantly increased growth hormone and insulin-like growth factor I levels to those of healthy young adults without serious adverse effects.

BENEFITS OF MK-677:

Studies have been on going with MK-677 since the late 90's. The list of benefits that have been found through this studies is not only significant in amount but in category as well. MK-677 has several different benefits and has shown to be helpful in a variety of ways. The main benefit that continues to be consistent is the increase in growth hormone and IGF-1 levels. This has shown to be the main benefit that is seen with MK-677. These increases are not small increases. They have shown to consistently be significant increases in both levels respectively. These are benefits that are extremely desirable but the list does not stop there. This results is consistent throughout the many clinical trials thus far. Below is a list of other significant benefits found through studies and implementation on humans:

Increases in fat free mass
Enhanced sleep quality
A treatment for obesity and fat loss
Lowering of bad cholesterol (LDL)
Significant improvements in nitrogen balance
Reversal of diet-induced nitrogen wasting
Treatment of catabolic conditions
Increase in basil metabolic rate
Oral administration (no injections required)
Overall sense of well-being

These benefits have all been seen with consistency throughout clinical studies. Human logs seen on many bodybuilding forums throughout the internet have also confirmed these benefits as been true and accurate. MK-677 has shown to increase muscle mass and bone density, while also decreasing fat mass. While many know that GH itself is very useful for fat loss, it has always fallen short in studies researching Growth Hormone’s effect on muscle protein synthesis. As can be seen by the extensive list, there is a significant size of benefits offered with implementation of MK-677. There is a sizable amount of intrigue and interest after seeing several results and studies that are consistent in showing the strong capabilities of MK-677. These factors, coupled with the little to no possible side-effects make MK-677 as very desirable addition into supplemental regiments for many individuals.


SIDE-EFFECTS:

Any time you are putting a substance into your body, it is is vital to know and understand the possible side-effects that could be endured. Whether these are probable or unlikely to occur, it is important to be fully educated on all possibilities and know how to treat them or control them if there is an occurrence. As stated above, one of the highly desirable attributes of use with MK-677 is the lack of side-effects present. Through intense research with human studies and personal logs, findings of side-effects are rare but there are small instances that need to be brought to attention.

The most frequent side-effects that were shown through human studies were increases in appetite, which is to be expected with the mimicking of ghrelin being involved. This showed to subside after 1-2 months of use. Other small side-effects present in some were mild lower extremity edema and muscle pain. There is a worry of prolactin increase as this is a common side effect with secretagogues, however human studies did not show this occurrence and this increase was reported on very rare occurrences in other logs reviewed. This is a problem that is not wanted at the peak of GH release if physical transformation is the intended goal. According to research, MK-677 increases GH and IGF-1 without a subsequent increase in Prolactin or Cortisol. GRF and GHRP-2,-6, all increase Prolactin and Cortisol, to a pretty significant degree. Ipamorelin stands alone as the only GHRP that has almost no effect on these other two hormones. So the fact that MK-677 increases growth hormone without the negative release of Prolactin and Cortisol is incredibly promising. By not increasing prolactin, MK-677 is a game changer as this is a substantial worry for many users. The last side-effect seen was extremely rare but was that of water retention. This is highly questionable as the subject was using other anabolics and supplements at the reported occurrence so a direct correlation with MK-677 may or may not be present. As can be ascertained from the list above, the side-effects are minimal at best.

STUDIES CONDUCTED:

There are studies dating back as far as 1997 with MK-677. Below, you will find a list of links with several studies conducted and a small description on what was being studied with MK-677 use. These are all human studies and provide substantial insight.


1997: Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults

http://press.endocrine.org/doi/full/10. ... 82.10.4297


1997: MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism

http://press.endocrine.org/doi/abs/10.1 ... lCode=jcem

1998: Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.

http://www.ncbi.nlm.nih.gov/pubmed/9661080

1997: Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.

http://www.ncbi.nlm.nih.gov/pubmed/9349662

1999: Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group.
http://www.ncbi.nlm.nih.gov/pubmed/10404019
2001: Effects of oral administration of ibutamoren mesylate, a non peptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children.

http://www.ncbi.nlm.nih.gov/pubmed/11452249

1997: Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure

http://press.endocrine.org/doi/full/10. ... .83.2.4539

This is a small sample of several studies conducted over time in regard to MK-677 use and the benefits its provides. The results have remained consistent, showing substantial benefits in each study.

DOSING:

When reading through the studies conducted, dosing ranged from 5mg-25 mg per day. The half life of MK-677 is 24 hours and is best tolerated when taken in the morning on an empty stomach. It provides a large improvement in sleep benefit however it can interfere with sleep if taken too late at night as opposed to the morning, making morning dosing optimal. The high end dosing protocol for MK-677 is 50 mg per day but it has shown to consistently be the best tolerated and show the most positive effect at 25 mg per day. It is fine to ease into it and assess your body response. It has shown to be best utilized in the safest and most effective manner at 25 mg per day. This dosing has shown to be the sweet spot. Many studies have shown MK-677 to be used in one and two year intervals with no adverse reactions and no desensitizing issues. This makes it very desirable for use as well.


CONCLUSION:

MK-677 is showing it's effectiveness regularly when implemented into supplementation. There are consistent findings and studies to back up all claims. There are major benefits show with use, especially in regard to consistent and large increases in IGF and GH levels. The large amount of benefits coupled with the miniscule amounts of side-effects make MK-677 extremely desirable. Research and study continues but through more than a decade of study, the results show MK-677 to be highly effective and beneficial in several aspects.


Awesome information Dylan! MK-677 looks even better than I anticipated. I'm very interested in the positive effects of it, and trying it out before going with GH which is obviously considerably more expensive. It appears that MK-677 can be ran and should be ran for a considerable amount of time (like GH) for best results. This is something I can't wait to try out for myself to see what it can do for me :D


Lets put it this way brother... 1. It should not be confused with GH as being as strong nor as effective HOWEVER, it has "GH Like properties and abilities which has earned it the synonym of "GH in a bottle." Just to be abundantly clear... I AM NOT SAYING NOR ADVOCATING IT to be the same or as strong etc. HOWEVER, it has MAJOR capabilities and for someone that is uncomfortable with GH use, THIS is the safer and best alternative to get LIKE results... 2. There's a reason you did not see as much on this as WE SHOULD HAVE because it would have directly taken out of the pockets of sarms1 ownership. They refused to ever add it to the lineup, despite SEVERAL months of my urging and YOU KNOW WHY, because of 2 reasons... The first being they simply did not offer it in the store and that would have sent customers elsewhere ultimately resulting in a loss of business as other companies were tried and see to be far better and two, the raws for 677 are 3-4 times more expensive and you cannot underdose this and get away with it all so they have no way to scam on it... The margins were not there enough, even though they would still be good but greed took away from something this amazing because it really is amazing if you have the quality... I am sure noone is surprised by the facts given about it though...


And everything you said, is exactly why I'm so glad that pure essence is releasing this MK-677. With the price of that compound, you most definitely want to make sure you are getting it from a high quality source. With the reputation of pure essence, I would say we are in very good hands!
 

DylanGemelli

Founding Member
Super Moderator
william32 said:
Good info. When is Pure Essence releasing theirs?


I don't have an exact date but from what I have been told, within the next 30 days brother... Of course, as soon as I have an exact date there will be an announcement and I already have been told I will be getting sent a pre release so I will start using it immediately upon receiving it
 

JackSteel

Banned
IMO GHRPs are better then GH because you're benefitting for higher levels of REAL pituitary produced GH from your own body. No synthetic recombinant HGH will be as effective iu-for-iu


Sent from my iPhone using Tapatalk
 

ibleedoranbla

Active member
Re: RE: Re: What is MK-677?? IN DEPTH ARTICLE BY: Dylan Gemelli

DylanGemelli said:
william32 said:
Good info. When is Pure Essence releasing theirs?


I don't have an exact date but from what I have been told, within the next 30 days brother... Of course, as soon as I have an exact date there will be an announcement and I already have been told I will be getting sent a pre release so I will start using it immediately upon receiving it
I'm definitely interested in giving it a go. I'm using some now but who knows if it's real. At least from pure essence I'll be able to be at peace knowing if it's real or not.
 

ibleedoranbla

Active member
Re: RE: Re: What is MK-677?? IN DEPTH ARTICLE BY: Dylan Gemelli

JackSteel said:
IMO GHRPs are better then GH because you're benefitting for higher levels of REAL pituitary produced GH from your own body. No synthetic recombinant HGH will be as effective iu-for-iu


Sent from my iPhone using Tapatalk
I completely agree and not to mention you don't have too worry about shutting down your own pituitary gland. People worry about shutting down their hpta but I'd be way more concerned with screwing up my pituitary. Pituitary, thyroid and pancreas are just things I have no intention on screwing with.
 

RickRock

Community Leader
VIP Moderator
JackSteel said:
IMO GHRPs are better then GH because you're benefitting for higher levels of REAL pituitary produced GH from your own body. No synthetic recombinant HGH will be as effective iu-for-iu


Sent from my iPhone using Tapatalk


That's an interesting way of looking at it, but I can't argue with your point. It's certainly much more cost effective as well
 

RickRock

Community Leader
VIP Moderator
DylanGemelli said:
william32 said:
Good info. When is Pure Essence releasing theirs?


I don't have an exact date but from what I have been told, within the next 30 days brother... Of course, as soon as I have an exact date there will be an announcement and I already have been told I will be getting sent a pre release so I will start using it immediately upon receiving it


That's awesome to hear brother. Looking forward to trying out pure essence MK-677 once it drops
 

DylanGemelli

Founding Member
Super Moderator
I can tell you this, the SECOND i know its coming, I will be the first to have it (don't be jealous but i have try it for everyone LOLLLLL) and I will make sure to post pics and I am going to do my best to keep detailed results etc... This could be a real big deal for me personally because of my inability to use regular GH as well... I am HIGHLY anticipating this... This is one of the most commonly faked or underdosed sarms out there especially because of the cost... That WILL NOT be an issue from Pure Essence, I GUARANTEE THAT
 

gymrat827

Member
JackSteel said:
IMO GHRPs are better then GH because you're benefitting for higher levels of REAL pituitary produced GH from your own body. No synthetic recombinant HGH will be as effective iu-for-iu


Sent from my iPhone using Tapatalk


Try sero's bud. your opinion will radically change.
 

RickRock

Community Leader
VIP Moderator
Re: RE: Re: What is MK-677?? IN DEPTH ARTICLE BY: Dylan Gemelli

jjfingers said:
Like GH this is to be ran at longer durations correct? When can one start to see the benefits of this compound?
Yes, from what I understand you want to run MK-677 for longer periods. As for when to start seeing results, I'm really not sure. A lot of that is probably very user specific
 

cybrsage

Member
DylanGemelli said:
I can tell you this, the SECOND i know its coming, I will be the first to have it (don't be jealous but i have try it for everyone LOLLLLL) and I will make sure to post pics and I am going to do my best to keep detailed results etc... This could be a real big deal for me personally because of my inability to use regular GH as well... I am HIGHLY anticipating this... This is one of the most commonly faked or underdosed sarms out there especially because of the cost... That WILL NOT be an issue from Pure Essence, I GUARANTEE THAT

Way to take one for the team! Thanks! ;)
 
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