bannednutritionnapsgear

In the discussion of enlarged prostrate , caused by high E or DHT....

Or maybe its both?? DHT can cause enlarged prostrat, thats why finasteride helps but I have been reading the forums for about 8 yrs now and I have seen it mentioned that enlarged prostate happens from AAS mainly testosterone because it is the unmanaged high E2 causing the growth. I also have read that its the DHT that enlarges the prostate but its the high E2 thats responsible for cancer.

Doing research on S4 leads me to this Wiki. So S4 has been used in clinical trails to block DHT and NOT break down muscle with out the horrible side effects of finasteride.

Is there any evidence at this ti,e that S4 reduces the chances of prostate cancer??



From Wikipedia, the free encyclopedia
Andarine
Andarine.svg
Systematic (IUPAC) name
(2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
Clinical data
Legal status
Investigational new drug
Identifiers
CAS Registry Number 401900-40-1
ATC code None
PubChem CID: 9824562
IUPHAR/BPS 7849
DrugBank DB07423 Yes
ChemSpider 8000309 Yes
ChEMBL CHEMBL125236 Yes
Chemical data
Formula C19H18F3N3O6
Molecular mass 441.357 g/mol
SMILES[show]
InChI[show]
(what is this?) (verify)
Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,[1] using the non-steroidal androgen antagonist bicalutamide as a lead compound.[2]

Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.[3] This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.[4]

References[edit]
Jump up ^
 
Kept reading and answered my own quest.....It says BICALUTAMIDE is the lead compouns in S4 and that answers all questions... Bicalutimide is used to treat cancer.

If you are to research S4 then it makes sense to read about Bicalutimide.
 

cbbram

Community Leader
VIP Moderator
My prostate was bothering me during my blast (frequent urination and some discomfort) and my blood test revealed my estrogen was high. Not terribly high, but it was out of range (estradiol 58). I increased my Aromasin to 12.5mg ed and it made a big improvement. I'm also supplementing Saw Palmetto.
 

RickRock

Community Leader
VIP Moderator
Or maybe its both?? DHT can cause enlarged prostrat, thats why finasteride helps but I have been reading the forums for about 8 yrs now and I have seen it mentioned that enlarged prostate happens from AAS mainly testosterone because it is the unmanaged high E2 causing the growth. I also have read that its the DHT that enlarges the prostate but its the high E2 thats responsible for cancer.

Doing research on S4 leads me to this Wiki. So S4 has been used in clinical trails to block DHT and NOT break down muscle with out the horrible side effects of finasteride.

Is there any evidence at this ti,e that S4 reduces the chances of prostate cancer??



From Wikipedia, the free encyclopedia
Andarine
Andarine.svg
Systematic (IUPAC) name
(2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide
Clinical data
Legal status
Investigational new drug
Identifiers
CAS Registry Number 401900-40-1
ATC code None
PubChem CID: 9824562
IUPHAR/BPS 7849
DrugBank DB07423 Yes
ChemSpider 8000309 Yes
ChEMBL CHEMBL125236 Yes
Chemical data
Formula C19H18F3N3O6
Molecular mass 441.357 g/mol
SMILES[show]
InChI[show]
(what is this?) (verify)
Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy,[1] using the non-steroidal androgen antagonist bicalutamide as a lead compound.[2]

Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.[3] This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.[4]

References[edit]
Jump up ^


That is some really really incredible information brother! I think this is something that obviously needs more research, but it certainly appears that S4 can possibly help reduce the chance of cancer, particularly in the prostate. If so, that is very good news for AAS users, because of the increased risks with AAS use. Another valid reason to use S4 on cycle, which I do almost every cycle myself! Thank you so much for sharing this!
 

DylanGemelli

Founding Member
Super Moderator
THANK YOU for posting... yes, this is indeed true... the problem is it has not been tested enough to show that s4 itself can treat cancer but all studies that have been conducted to show it to have that ability... THANK YOU for bringing this to light because it definitely adds another quality that makes it even more desirable...
 
Yeah its funny cause I have been reading alot and I am trying to find anything that can show adverse sides to sarms. So in this case i found something good here!
 

DylanGemelli

Founding Member
Super Moderator
Yeah its funny cause I have been reading alot and I am trying to find anything that can show adverse sides to sarms. So in this case i found something good here!

thats excellent and truly appreciated bro.... its just a further indication of the many qualities they possess and its great you brought this to light... thanks again
 

rockmfhudd

Active member
Here is a link for you to read up on.It is long but it is thorough.It is from the Life Extension folks.I write for them from time to time.They are for real.

http://www.lifeextension.com/magazi...tosterone-replacement-prostate-cancer/page-01

Fucking DRB welcome back bud, I certainly missed you and hope you hang around as long as you can between banana harvests hell you can get some national geographic bitches with there titties hangin out to do all that for you, you can just sit back and watch hahahaha the fine ticas in costa rica national geographic im talkin about
 
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