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HGH Information - Dosage for Men and Women - Use and Abuse

ErTetris

Member
This is a topic of my interest. Please, if you have any editing suggestions, let me know and I'll make changes.
The following information were extracted from online sources. Link to the sources were provided.

Part 1
HGH Benefits ( http://hgh.bz/HGH_Dosage.php)

Is taking HGH healthy? There are good health reasons for taking HGH which is why it has grown to be so popular as a treatment for hormone deficiency and imbalance.
The human growth hormone, commonly called somatropin is a protein consisting of 191 amino acids. The human body naturally produces it every day through secretion of the pituitary gland located in the brain. It is then released into the bloodstream in small pulses during sleep at night when the human growth hormone is at its peak and during high-intensity exercise. Despite the fact that it is in the blood for only a few minutes, it is one of the most powerful hormones and impacts all body functions, tissues and organs. Immediately after it is secreted it is absorbed by the liver and sent throughout the body to grow, rejuvenate, repair and regenerate cells. Normal levels of HGH help the body maintain its youthful appearance by maintaining bodily functions vital for health. Its ability to grow new muscle cells, regenerate cells, reduce adipose fatty tissue, boost sex drive, enhance mood, smooth skin, improve the immune system and cardiovascular health have given human growth hormone a reputation for helping support healthy aging.

HGH is a subcutaneous injection. When injected subcutaneously in the fatty tissue, the bio-availability of HGH is approximately 75%. When somatropin is injected intramuscularly, the bioavailability is reduced to approximately 60% to 63%. Proper storage of your GH drugs is required to ensure full potency or bio-activity. This is especially true of each doe you measure after reconstitution.

Somatropin's Half-Life: When injected subcutaneously, the half-life of HGH is approximately 3.8 hours. When injected intramuscularly, the half-life of HGH is approximately 4.9 hours. While the half-life of growth hormone is short regardless of the mode of administration, keep in mind the total affects of normalizing the body's hormone levels far outlast the brief half-life. The significant and dramatic increases in IGF-1 levels brought on by the hormone's use lasts beyond the 24 hours which is why HGH is prescribed for daily daily shot administration. As for the bioavailability, you can obtain the targeted medical results with either injections method and patients are known to use somatropin as subcutaneous injections as well as intramuscular. However, the overwhelming number of patients taking injectable Human Growth Hormone take their daily doses subcutaneously which provides for a stronger concentration of the drug introduced into the body over a 24 hour period.

Growth Hormone Doses for Men
In a therapeutic or clinical setting, the most common male Human Growth Hormone doses will fall in the 1-3IU per day range. Most men will, however, fall in the 2IU range for daily somatropin shots. Some men may be prescribed as much as 4IU's per day, but this is a relatively high dose many times used by athletes and body builders and such therapeutic somatropin HGH doses are rare. Very low doses taken steadily are quite common in long-term bio-identical HRT and anti-aging plans.
For men who have lowered libido and lost muscle, the enhanced stamina, endurance and exercise recovery growth hormone replacement provides helps them regain sex drive, muscle bulk and size. In addition, HGH provides men with age-related health rejuvenation, vigor and vitality, thicker hair, smoother skin, stronger bone and mineralization.

Growth Hormone Dosage and Testosterone for Women
HGH for women is prescribed in a smaller dosage than for men and because the production of estrogen is correlated with levels of human growth hormone, a treatment program that optimizes and balances all of a women's hormones is necessary when taking hormone replacement drugs. The more estrogen a women has in her system the more growth hormone, so estrogen replacement is many times done in concert with HGH replacement. Typical HGH doses for women are 1IU to 2IU daily injected by subcutaneous shots in the fatty tissue. Women may naturally make more growth hormone than men but because they have much less testosterone do not develop muscular physiques as do men. HGH, estrogen and progesterone have help maintain healthy hair, smooth skin, and strong nails. When women go through menopause wrinkled skin, dry hair, cracked nails, bone loss, weight gain with increased body fat can cause signs of premature aging. Hormone therapy is designed to help women combat these symptoms as well as the more well-known physiological symptoms of hot flashes, night sweats, anxiety, headaches mood swings, depression, vaginal dryness and loss of libido.
The most proper HGH doses for women maintain a delicate balance among all hormones and bio-identical replacement therapy programs include other hormones in addition to somatropin injections like testosterone, thyroid and estrogens. Testosterone is also important for women's health, especially sexual desire and is prescribed along with estrogen, progesterone, thyroid and human growth hormone when low testosterone levels are detected. Women taking doses of testosterone report increased sexual desire and vaginal sensitivity.

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Part 2
HGH Side Effects. ( http://hgh.bz/HGH_Abuse.php )
Abuse of HGH Human Growth Hormone has been shown to have serious side effects which include Carpal Tunnel Syndrome, Arthritis, Edema (swelling), Water Retention, Joint Pain, Gigantism (unnatural bone growth), Bloating, Liver damage, Insulin imbalance and Thyroid problems.

Symptoms of injecting too much Growth Hormone.
The symptoms listed for HGH abuse are typically experienced with higher than normal doses. You should also completely avoid HGH Therapy with Human Growth Hormone injections if you have cancer or at high risk for cancer, or have a family history of cancer. For example men with prostate cancer would not qualify for HGH therapy and should not entertain injecting growth hormone. Human Growth Hormone injections used for HGH therapy stimulate cell reproduction and regeneration which can have an amplifying and dangerous effect on a person with cancer. Although HGH doesn't cause cancer, taking HGH unnecessarily could increase cancer risk in people predisposed to cancer or accelerated the rate of development in those that already have it. For this reason HGH abuse is a serious and controversial subject. The potential health benefits of human growth hormone should outweigh the possible risks and side effects that result from using it.

How to Avoid Side Effects of HGH Injections
Numerous studies have shown side effects can be avoided by slow initial administration, proper monitoring of HGH levels and usage of growth hormone on a daily basis in what is called a low-dose, high frequency method or protocol

Side Effects of HGH Abuse
Typically the most common side effect of the excess use of HGH is acromegaly (excess growth hormone). This is a medical condition that begins with the overgrowth of facial bone and connective tissue, leading to a changed appearance due to protruding jaw and enlarged eyebrow bones. This condition also leads to an abnormal lengthening and growth of the hands and feet with an increased growth of hair all over the body. Contrary to the alleged longevity properties of HGH increasing your life, this condition of excessive HGH will shorten life expectancy considerably.

Side effects of too much HGH.
Acromegaly (as described in detail above)
Premature death (in case of acromegaly)
Heart enlargement (due to prolonged use of HGH. Can't be reversed)
Low blood sugar with risk of going into a diabetic coma
Excessive hair growth all over the body
Excessive water retention
Liver damage
Thyroid damage
Diabetes onset

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Part 3

How to increase HGH?
HGH can be increased via administration of synthetic HGH or by stimulating your natural production using HGH secretagogues, HG-Releasing Hormone (HGRH), or GH-releasing Peptide (GHRP).

HGH
Half-life: 20-30min, with peak blood concentrations between 2-6h after injection
Also known under the pharmaceutical name of Somatropin, Genotropin, Humatrope, Nutropin.
Made up of a blend of 191 amino acids, it’s a synthetic form of HGH made in labs. The body reacts to synthetic HGH in the same way as natural HGH. As stated previously, frequent administration is required, since it has a very short half-life. See part 1 and part 2 for additional HGH information.
“Sub-Q” injections are particularly noted for producing a localized loss of fat, requiring the user to change injection points regularly to even out the effect.
( http://www.peptidequestions.com/peptides/hgh-fragment-176-191/ )
( http://www.steroidology.com/human-growth-hormone-hgh-somatotropin/ )

HGH Fragment
Half-life: 20-30min, with peak blood concentrations between 2-6h after injection
The HGH Fragment is a modified form of amino acids 176-191 at the C-terminal region of the human growth hormone (HGH). Studies have shown that it works by mimicking the way natural HGH regulates fat metabolism but without the adverse effects on insulin sensitivity (blood sugar) or cell proliferation (muscle growth) that is seen with unmodified HGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis (breaking down of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids in the body).
HGH fragment 176-191 is meant to be 12.5 times stronger than human growth hormone (HGH) for weight loss than standard human growth hormone (HGH).
Of particular note is that in studies HGH fragment 176-191 had the ability to increase IGF-1 levels which translates into the fragments ability to give anti-aging effects.
( http://www.peptidequestions.com/peptides/hgh-fragment-176-191/ )

HGH Secretagogue, GH-releasing Hormone (GHRH), GH-releasing Peptide (GHRP)
This involves taking substances known as HGH secretagogue, GHRH, or GHRP that stimulates your body pituitary gland to produce additional growth hormone.
GHRH and GHRP can be combined to increase the body’s production of HGH.
(http://www.advancednaturalmedicine.com/live-longer-lose-weight/secretagogues-or-HGH-Supplements.html)

SARMS MK677 (Secretagogue)
Half-life: 24h
This is a liquid form which is suspended in alcohol and taken orally, averaging a dosage of 25mg per day.
Sold for research purposes by PureEssence at http://pureessenceresearch.com/product/mk-2866-2/
Increases natural GH production up to 80-90%over several months. Effectiveness increases with time and it doesn’t seem to build tolerance.
Remaining active for roughly 24 hours, MK-677 works in a pulsatile fashion, causing about a dozen bursts of GH throughout the day. This keeps GH levels elevated for a substantially longer period of time compared to some of the most commonly used GH peptides, such as GHRP-2 or GHRP-6, which only maintain elevated GH levels for around 90 minutes. From a pharmacokinetic standpoint, in terms of duration of action, this makes MK-677 much more similar to exogenous growth hormone than most other GH peptides.
(https://www.ironmagresearch.com/mk-677-the-best-growth-hormone-secretagogue/)

GHRP-6(GHRP) - First Generation Peptide
Half-life: 15-60 min
GHRP-6 is most generally used for the same purposes that GH might be used, but may be chosen where a cost advantage exists favoring GHRP-6, GH is not available, or the individual prefers the idea of stimulating his own GH production to injecting GH.
Doubting that GHRP-6 use is likely to cause gynecomastia (gyno), elevation of prolactin from GHRP-6 use can be problematic for some individuals who already have gyno, including undetected gyno which developed during puberty. Ipamorelin can be a better choice of GHRP for such individuals.
(https://thinksteroids.com/steroid-profiles/ghrp-6/)

GHRP-2(GHRP) - Second Generation Peptide
Half-life: 15-60 min
GHRP-2 is considered to be a true HGH secretagogue, meaning that it stimulates the body’s own secretion of HGH. GHRP2 has demonstrated that it is very effective at stimulating GH production in research test subjects. GHRP-2 is a 2nd generation GHRP just behind GHRP-6. Compared to GHRP-6, GHRP-2 is considered to be much more superior in terms of growth hormone stimulation because over longer periods of time it maintains maximum elevations in Growth Hormone. GHRP-2 has shown to increase IGF-1 levels (Insulin Like Growth Factor 1), and even greater results happen when used with Growth Hormone Releasing Hormone (GHRH). It has a short half life with peak concentrations occurring around 15 minutes but not longer than 60 minutes. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to the high-amplitude pulsation from the GHRP-2. GHRP-2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or somatotrope by other means. Unlike ghrelin, GHRP-2 is not lipogenic which means that it does not induce fat storage. Although ghrelin plays a large role in hunger, GHRP-2 as an analog of ghrelin does not increase appetite significantly.
(http://www.peptidesciences.com/ghrp-2)

Hexarelin (GHRP)
Half-life: 70 minutes
Hexarelin (HEX) is a peptide GH secretagogue, structurally similar to GHRP-6, in the growth factor family which stimulates the release of growth hormone (GH).
There is no appetite boost with Hexarelin use (as opposed to GHRP-6’s extreme appetite increase) due to its inability to drastically increase Ghrelin levels that are responsible for added hunger and quicker gastric emptying.
Due to Hexarelin’s ability to increase secretion of natural Growth Hormone, most of its effects are similar to those of synthetic GH, although to a slightly lesser extent. Also, the GH receptors in adipose (fat) tissue allow for potential fat reduction with Hexarelin use. The increase of circulating GH through Hexarelin use causes levels of Insulin-Like Growth Factor (IGF-1) to rise in the liver. IGF-1 is the prime cause of muscle growth in response to GH stimulation.
In studies where Hexarelin was injected subcutaneously, Growth Hormone, measured through plasma concentrations, increased significantly and within thirty minutes of injection. GH levels decreased back to normal around four hours post injection. The GH increase, has been found to be effective up to 2mg/kg, any further increase in dose was found to be ineffective in causing a GH response .
Results showed that Hexarelin’s effect on GH stimulation tapered between weeks 4 through 16. Separating cycles by 4 week off periods, avoided the negative feedback loop and the next cycle of Hexarelin produced the same level of results as the first cycle.
(https://thinksteroids.com/steroid-profiles/hexarelin/)

Ipamorelin (GHRP) - Third Generation Peptide
Half-life: 2 hours
Ipamorelin is a 3rd generation GHRP behind GHRP-6 and GHRP-2. Ipamorelin has very similar characteristics of GHRP-2: does not have ghrelin's lipogenic properties and does not promote hunger.Pamorelin is one of the cleanest, most versatile and safest GHRP’s out there. The pentapeptide Ipamorelin is somewhat like Hexarelin, but it’s cleaner. In some ways, it acts like GHRP-6 or GHRP-2 without the sloppy sides of elevated hunger issues. Ipamorelin shares similar functionality to Hexarelin and compared to other peptides, it is a much more stable form of ghrelin and has longer half-life periods of at least two hours long and causes secondary effect by making neurons to become excited.
When it comes to peptides, you are going to want a slow and steady release for a strong, clean pulse that mimics natural GH release times. This is going to be better for gains and keeping unwanted side effects down. Ipamorelin acts like a ghrelin mimetic, but, unlike GHRP-6, it has shown to be more stable in suppressing somatostatin and stimulating GH release.
Ipamorelin has been shown to be both highly potent and very selective in vivo and vitro situations, and has also demonstrated good safety and tolerability in human clinical studies.
(http://www.rxmuscle.com/rx-chem/chemical-enhancement-articles/9572-how-it-works-growth-hormone-peptide-family.html)
( http://www.peptidesciences.com/ipamorelin )

CJC 1295 with DAC (GHRH)
Half-Life: 1 week
CJC 1295 without DAC is a 30 amino acid peptide hormone, better known in the community as a GHRH (growth hormone releasing hormone). Essentially, what this means is this peptide will release a series of pulses over a long period of time which usually equates to fewer injections.
http://www.anabolicsteroids.net/cjc-1295.php
What this means is that every time the body experience a GH pulse there is an increase in natural growth hormone release over the course of several days. It has been found that a single dose of cjc 1295 dac can increase GH levels 2-10 times up to 6 days later!
DOSAGE: 2mg x1 per week
(http://uspeptides.com/articles/cjc-1295-info-in-plain-english/)

CJC 1295 without DAC (also known as MOD GRF1-29) (GHRH)
Half life: 30 minutes
Mod GRF 1-29 and CJC-1295 are still being researched. As such, they are not yet medically utilized or approved. Though some firm protocols for the use of these peptides have been developed, the dosage of the compound is not yet medically confirmed. In a study conducted by researchers on 21 to 61 year-old subjects, it was found that depending on the dose, the concentrations of the growth hormone increased to up to 10 times for at least 6 days. Also, the concentration of IGF-1 increased to up to 3 times for 9 to 11 days.
DOSAGE: CJC-1295 and Mod GRF 1-29 are administered in micrograms (mcg) rather than milligrams (mg) – the unit of administration of other steroids and performance-enhancing drugs. It has also been found that a 100mcg dose is enough to fully saturate the receptors in the anterior pituitary. This is called the saturation dose. After a dose of 100mcg has been administered, the subsequent dosages will achieve only half the effect.
(http://www.anabolicsteroids.net/cjc-1295.php)

CJC-1295 with DAC versus CJC-1295 Without DAC
CJC-1295 with DAC and CJC-1295 without DAC (also known as Modified GRF 1-29) are both Growth Hormone Releasing Hormones (GHRH). Their action in the human body is identical but the difference between the two peptides are the span of the half-life. Modified GRF 1-29 have a very short acting half-life of about 30 minutes, while CJC-1295 DAC has a half-life that can last up to approximately 8 days. Many a scientist have reported that the short half-life of Modified GRF 1-29 is considered to be much more natural as they produce a short pulse of Human Growth Hormone.
(http://www.peptidesciences.com/cjc-1295)

HGH PCT
Synthetic IGF and GH use produces a shutdown of your endogenous levels of those hormones, Hexarelin seems very useful for “GH-PCT” or “IGF-PCT”, as it can help restore your natural levels of those hormones after a cycle of them.
(https://thinksteroids.com/steroid-profiles/hexarelin/)

Notes
Natural body GH production is not constant during the day, but it happens in intervals. Short half-life products seems to mimic the natural body's production of GH, which occurs in interval pulses. Short half-life products requires administration 2-4 times per day. Long half-life products such as CJC-1295 DAC can be administered once per week.
After administering a short-life growth hormone, wait about half an hour before consuming a meal. At this point, the hormone has started to take effect and you are allowed to eat whatever you want. This doesn’t apply to long half-life GH such as CJC-1295 with DAC, since the user can eat anytime.
 
Great info!!! I took HGH with my first cycle last year and getting ready to start back on tomorrow for a bridge into my next cycle in April.
 
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