Yes because twice a week you will have steady blood levels. If you inject once a week at the end of the week your levels will be below half of what you injected. You will have more sides and most likely feel tired.
If it's a temporary thing that you need to do occasionally sure but it's not something I would do long term.
If you want to inject once a week for TRT use something that was intended for it such as Sustanon. It has short esters that peak during the week and a long ester to back you up until the next week. It will take about a month for Sustanon's long ester to reach peak levels.