Watched the new Nolvadex video. Enjoyed the way it was explained. One question though when he mentioned Clomid. It sounded like Nolvadex is more significant in blocking estrogen than Clomid. Also Nolvadex helps the pituitary gland release LH, which Clomid does not do. So the question, why take Clomid on my PCT if Nolvadex is so much better? Is the Clomid in fact there for something lacking or lagging?
Clomid and Nolva both work in different pathways to stimulate test production, so the combo of the two are ideal for the best recovery. It's that in a nutshell.
Here is a little write up I did on Clomid a couple years ago
Clomiphene Citrate and Testosterone production
Clomid was originally developed to treat infertility in women by stimulating ovulation. However, to males there are also some very big benefits. Clomid has become the popular SERM of choice for many of those in the bodybuilding world to increase the production of testosterone after a steroid cycle, and for very good reasons. It has a lot of benefits to those that cycle steroids, and has become a big part of Post Cycle Therapy.
It is said that Clomid “stimulates” production of luteinizing hormone (LH) and therefore production of testosterone, but in fact Clomid achieves this not by stimulation of the hypothalamus and pituitary, but by blocking their inhibition by estrogen. This allows LH levels to return to normal, or even above normal levels, and consequently, natural testosterone levels to also normalise or rise above normal levels.
Clomid is an estrogen agonist and antagonist Making it an activator and blocker at the same time. This happens based on the tissue. In some tissues, Clomid acts as an activator (agonist), where others it acts as a blocker (antagonist).
Clomid is referred to as a selective estrogen receptor modulator (SERM) like Tamoxifen Citrate (Nolva). They both work alike in the fact that they are both estrogen receptor antagonists. Both of these compounds are antiestrogenic in breast tissue, fat tissue, the hypothalamus, which is ideal for bodybuilding.
They are also estrogenic in bone tissue and have a positive effect on lipid profile (cholesterol levels). Clomid also reduces the exercise-induced damage of muscle tissue which can be beneficial to endurance athletes. There is some indication that Clomid can have estrogenic effects on mood, causing some slight depression, however this is dose and user dependent, and not a common issue when taking a recommended dose.
Clomid is weaker than Nolva when looking at them mg for mg. it takes about 150mg of Clomid to equal 20mg of Nolva. However much lower doses of Clomid at around 50mg have been shown to very effective at raising testosterone levels. Higher levels of Clomid (over 100mg) is where emotional side effects and possible vision complications can come into play.
Clomid, just like nolvadex, is very safe for long term treatment of lowered testosterone levels, with studies showing it is safe to use for up to four months. And post-cycle, when steroid users are suffering form lowered testosterone levels from coming off-cycle, is when clomid is most effective.