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Metformin in cancer prevention and therapy

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The prevalence of diabetes is dramatically increasing worldwide. The results of numerous epidemiological studies indicate that diabetic population is not only at increased risk of cardiovascular complications, but also at substantially higher risk of many forms of malignancies. The use of metformin, the most commonly prescribed drug for type 2 diabetes, was repeatedly associated with the decreased risk of the occurrence of various types of cancers, especially of pancreas and colon and hepatocellular carcinoma.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200668/

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According to the American Diabetes Association, there is mounting evidence that there is no relationship between use of metformin and the incidence of cancer. In other words, metformin neither protects against cancer nor makes it more likely than persons who take it will develop cancer https://www.thediabeteself.net/supplements/glucotype-2-review-what-is-it/ . The studies that appeared to show a reduction in cancer incidence among those who take or have taken metformin, in retrospect, underestimated the incidence of cancer in those who took metformin and/or an underestimate of the incidence of cancer in those who never took metformin.
 
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